Effect of dietary supplementation of nuts: in the development of atherosclerosis in an animal model lacking apolipoprotein E, search for new biomarkers in humans. (Q3157925): Difference between revisions
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(Created claim: summary (P836): The consumption of nuts within a healthy diet is associated with a low incidence of cardiovascular disease, reduce oxidative damage caused by lipids and lipoproteins and help prevent the development of atherosclerosis. Using the apoE-free mouse we have shown a decrease in atherosclerotic injury by providing a diet enriched in a mixture of nuts compared to a palm oil diet in females. This effect appears to be related to a reduction in non-HDL cho...) |
(Changed label, description and/or aliases in en: translated_label) |
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Effect of dietary supplementation of nuts: in the development of atherosclerosis in an animal model lacking apolipoprotein E, search for new biomarkers in humans. | |||
Revision as of 16:11, 12 October 2021
Project Q3157925 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Effect of dietary supplementation of nuts: in the development of atherosclerosis in an animal model lacking apolipoprotein E, search for new biomarkers in humans. |
Project Q3157925 in Spain |
Statements
16,750.0 Euro
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33,500.0 Euro
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50.0 percent
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1 January 2014
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31 March 2017
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INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD
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41°39'7.67"N, 0°52'51.38"W
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50297
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El consumo de frutos secos dentro de una dieta saludable está asociado con una baja incidencia de enfermedad cardiovascular, disminuyen el daño oxidativo causado por los lípidos y lipoproteínas y ayudan a prevenir el desarrollo de la aterosclerosis. Usando el ratón carente de apoE hemos demostrado la disminución de la lesión aterosclerótica al suministrar una dieta enriquecida en una mezcla de frutos secos en comparación con una dieta de aceite de palma en hembras. Este efecto parece estar relacionado con una reducción del colesterol no HDL, con una mayor expresión hepática de PON2 y una mayor protección a la oxidación de las LDL. En todos los frutos secos muchos de sus antioxidantes están localizados en la piel y el 50% o más de ellos se pierden cuando la piel es eliminada, hecho que raramente se ha tenido en consideración en los primeros estudios con frutos secos. La contribución de los componentes individuales de la nuez en el desarrollo de la aterosclerosis aún no ha sido evaluada. El presente proyecto pretende abordar los siguientes objetivos:1) avanzar en la investigación de los mecanismos por los cuales la nuez o su piel ejercen su acción sobre el desarrollo de la lesión ateroesclerótica. 2) caracterización de nuevos marcadores en plasma y su aplicación clínica en aterosclerosis. Utilizaremos para ello muestras de plasma de pacientes a los que se les administró durante 12 semanas una dieta saludable suplementada con o sin frutos secos. (Spanish)
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The consumption of nuts within a healthy diet is associated with a low incidence of cardiovascular disease, reduce oxidative damage caused by lipids and lipoproteins and help prevent the development of atherosclerosis. Using the apoE-free mouse we have shown a decrease in atherosclerotic injury by providing a diet enriched in a mixture of nuts compared to a palm oil diet in females. This effect appears to be related to a reduction in non-HDL cholesterol, with increased hepatic expression of PON2 and greater protection against oxidation of LDLs. In all nuts many of their antioxidants are located on the skin and 50 % or more of them are lost when the skin is removed, a fact that has rarely been considered in early nut studies. The contribution of the individual components of the walnut in the development of atherosclerosis has not yet been evaluated. This project aims to address the following objectives:1) To advance the investigation of the mechanisms by which the walnut or its skin exert its action on the development of the atherosclerotic lesion. 2) Characterisation of new plasma markers and their clinical application in atherosclerosis. We will use plasma samples from patients who were given a healthy diet supplemented with or without nuts for 12 weeks. (English)
12 October 2021
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Zaragoza
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Identifiers
PI13_02600
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