Cronodieta, Polymorphisms of Circadian Clock Regulator Genes, Weight Change and Obesity in the European Prospective Study on Nutrition and Cancer (EPIC Spain) (Q3155423): Difference between revisions
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(Removed claim: summary (P836): Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of...) |
(Created claim: summary (P836): Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of v...) |
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Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of various obesity rates at the present time. 2) Study the relationship of specific polymorphisms in the regulatory genes of circadian clocks (Clock, Bmal1, Per, Cry, Rev-erba) with chronodiet, chronotype and sleep pattern in different Spanish populations participating in the Epic cohort. Methods: Multicenter prospective cohort study integrated in the Epic-Spain cohort. The variables of exposure (chronodiet and polymorphisms of clock genes), intermediate (chronotype and sleep pattern), confusion (tobacco, physical activity, medication taking, reproductive history) and endpoints of the study (weight changes and various obesity rates) will be measured in 5,600 people (1120 in each center) who will be interviewed using standardised questionnaires, which will be carried out blood extractions and taking anthropometric measurements and electrical bioimpedance. After 18 months the anthropometry will be repeated to evaluate the effect of the timing on weight change. Generalised linear models and logistic regression models will be used to analyse the relationship between the exposure variables and the resulting variables. (English) | |||||||||||||||
| Property / summary: Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of various obesity rates at the present time. 2) Study the relationship of specific polymorphisms in the regulatory genes of circadian clocks (Clock, Bmal1, Per, Cry, Rev-erba) with chronodiet, chronotype and sleep pattern in different Spanish populations participating in the Epic cohort. Methods: Multicenter prospective cohort study integrated in the Epic-Spain cohort. The variables of exposure (chronodiet and polymorphisms of clock genes), intermediate (chronotype and sleep pattern), confusion (tobacco, physical activity, medication taking, reproductive history) and endpoints of the study (weight changes and various obesity rates) will be measured in 5,600 people (1120 in each center) who will be interviewed using standardised questionnaires, which will be carried out blood extractions and taking anthropometric measurements and electrical bioimpedance. After 18 months the anthropometry will be repeated to evaluate the effect of the timing on weight change. Generalised linear models and logistic regression models will be used to analyse the relationship between the exposure variables and the resulting variables. (English) / rank | |||||||||||||||
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| Property / summary: Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of various obesity rates at the present time. 2) Study the relationship of specific polymorphisms in the regulatory genes of circadian clocks (Clock, Bmal1, Per, Cry, Rev-erba) with chronodiet, chronotype and sleep pattern in different Spanish populations participating in the Epic cohort. Methods: Multicenter prospective cohort study integrated in the Epic-Spain cohort. The variables of exposure (chronodiet and polymorphisms of clock genes), intermediate (chronotype and sleep pattern), confusion (tobacco, physical activity, medication taking, reproductive history) and endpoints of the study (weight changes and various obesity rates) will be measured in 5,600 people (1120 in each center) who will be interviewed using standardised questionnaires, which will be carried out blood extractions and taking anthropometric measurements and electrical bioimpedance. After 18 months the anthropometry will be repeated to evaluate the effect of the timing on weight change. Generalised linear models and logistic regression models will be used to analyse the relationship between the exposure variables and the resulting variables. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:50, 12 October 2021
Project Q3155423 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Cronodieta, Polymorphisms of Circadian Clock Regulator Genes, Weight Change and Obesity in the European Prospective Study on Nutrition and Cancer (EPIC Spain) |
Project Q3155423 in Spain |
Statements
31,000.0 Euro
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62,000.0 Euro
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50.0 percent
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1 January 2016
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30 September 2020
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE NAVARRA
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42°49'6.42"N, 1°38'39.34"W
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31201
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Hipótesis: La distribución de la ingesta de energía y macronutrientes a lo largo del día (cronodieta) es un factor de riesgo modificable que podría estar implicado en la actual epidemia de obesidad. Determinados polimorfismos en los genes reloj podrían modular esa relación a través del cronotipo (patrón circadiano de vigilia) y el patrón de sueño. Objetivos: 1) Estudiar la relación de la cronodieta con el cambio de peso tras 18 meses de seguimiento y con la prevalencia de diversos índices de obesidad en el momento actual. 2) Estudiar la relación de polimorfismos específicos en los genes reguladores de los relojes circadianos (Clock, Bmal1, Per, Cry, Rev-erba) con cronodieta, cronotipo y patrón de sueño en diferentes poblaciones españolas que participan en la cohorte del Epic. Métodos: Estudio de cohorte prospectivo multicéntrico integrado en la cohorte Epic-España. Se medirán las variables de exposición (cronodieta y polimorfismos de genes reloj), intermedias (cronotipo y patrón de sueño), confusión (tabaco, actividad física, toma de medicación, historia reproductiva) y puntos finales del estudio (cambios de peso y diversos índices de obesidad) en 5600 personas (1120 en cada centro) que serán entrevistadas mediante cuestionarios estandarizados, a las que se le realizarán extracciones de sangre y toma de medidas antropométricas y de bioimpedancia eléctrica. Al cabo de 18 meses se repetirá la antropometría para evaluar el efecto de la cronodieta sobre el cambio de peso. Para analizar la relación entre las variables de exposición y las variables resultado se utilizarán modelos lineales generalizados y modelos de regresión logística. (Spanish)
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Scenario: The distribution of energy and macronutrient intake throughout the day (chronodiet) is a modifiable risk factor that could be involved in the current obesity epidemic. Certain polymorphisms in clock genes could modulate that relationship through the chronotype (circadian waking pattern) and sleep pattern. Objectives: 1) Study the relationship of chronodiet with weight change after 18 months of follow-up and with the prevalence of various obesity rates at the present time. 2) Study the relationship of specific polymorphisms in the regulatory genes of circadian clocks (Clock, Bmal1, Per, Cry, Rev-erba) with chronodiet, chronotype and sleep pattern in different Spanish populations participating in the Epic cohort. Methods: Multicenter prospective cohort study integrated in the Epic-Spain cohort. The variables of exposure (chronodiet and polymorphisms of clock genes), intermediate (chronotype and sleep pattern), confusion (tobacco, physical activity, medication taking, reproductive history) and endpoints of the study (weight changes and various obesity rates) will be measured in 5,600 people (1120 in each center) who will be interviewed using standardised questionnaires, which will be carried out blood extractions and taking anthropometric measurements and electrical bioimpedance. After 18 months the anthropometry will be repeated to evaluate the effect of the timing on weight change. Generalised linear models and logistic regression models will be used to analyse the relationship between the exposure variables and the resulting variables. (English)
12 October 2021
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Pamplona/Iruña
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Identifiers
PI15_02181
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