Q3158664 (Q3158664): Difference between revisions
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(Created claim: summary (P836): This study aims to develop an algorithm and a strategy to analyse various embryonic variables, such as oxidative stress and the prosthetic profile, in an IVF laboratory and to investigate and validate the use of both as biomarkers for embryonic viability in human IVF and their use as additional markers for the existence of morphokinetic markers provided by sequential technology._x000D_ _x000D_ The objective of this project is to investigate new...) |
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This study aims to develop an algorithm and a strategy to analyse various embryonic variables, such as oxidative stress and the prosthetic profile, in an IVF laboratory and to investigate and validate the use of both as biomarkers for embryonic viability in human IVF and their use as additional markers for the existence of morphokinetic markers provided by sequential technology._x000D_ _x000D_ The objective of this project is to investigate new predictive embryonic viability algorithms and the development of a system or analysis tool that includes the variables of oxidative imaging as a clinical expression. This will require the development of new functionalities and the validation of the functionality of the TCL Analyser system to make a better embryo selection during the in vitro fertilisation process, demonstrating their synergy with Time-Lapse systems. The TCL device must have the sensitivity needed to accurately test small samples (10-15 microlitres) of medium. _x000D_ _x000D_ as well as the comparison of the protein expression profiles of the human embryo using a proteomics-based strategy comparing the conditioned means of embryos, incubated in Time-Lapse, that implant against those who do not, allowing the development of a diagnostic tool based on the differential protein repertoire between both types of embryos. (English) | |||||||||||||||
| Property / summary: This study aims to develop an algorithm and a strategy to analyse various embryonic variables, such as oxidative stress and the prosthetic profile, in an IVF laboratory and to investigate and validate the use of both as biomarkers for embryonic viability in human IVF and their use as additional markers for the existence of morphokinetic markers provided by sequential technology._x000D_ _x000D_ The objective of this project is to investigate new predictive embryonic viability algorithms and the development of a system or analysis tool that includes the variables of oxidative imaging as a clinical expression. This will require the development of new functionalities and the validation of the functionality of the TCL Analyser system to make a better embryo selection during the in vitro fertilisation process, demonstrating their synergy with Time-Lapse systems. The TCL device must have the sensitivity needed to accurately test small samples (10-15 microlitres) of medium. _x000D_ _x000D_ as well as the comparison of the protein expression profiles of the human embryo using a proteomics-based strategy comparing the conditioned means of embryos, incubated in Time-Lapse, that implant against those who do not, allowing the development of a diagnostic tool based on the differential protein repertoire between both types of embryos. (English) / rank | |||||||||||||||
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| Property / summary: This study aims to develop an algorithm and a strategy to analyse various embryonic variables, such as oxidative stress and the prosthetic profile, in an IVF laboratory and to investigate and validate the use of both as biomarkers for embryonic viability in human IVF and their use as additional markers for the existence of morphokinetic markers provided by sequential technology._x000D_ _x000D_ The objective of this project is to investigate new predictive embryonic viability algorithms and the development of a system or analysis tool that includes the variables of oxidative imaging as a clinical expression. This will require the development of new functionalities and the validation of the functionality of the TCL Analyser system to make a better embryo selection during the in vitro fertilisation process, demonstrating their synergy with Time-Lapse systems. The TCL device must have the sensitivity needed to accurately test small samples (10-15 microlitres) of medium. _x000D_ _x000D_ as well as the comparison of the protein expression profiles of the human embryo using a proteomics-based strategy comparing the conditioned means of embryos, incubated in Time-Lapse, that implant against those who do not, allowing the development of a diagnostic tool based on the differential protein repertoire between both types of embryos. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:38, 12 October 2021
Project Q3158664 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3158664 in Spain |
Statements
165,969.5 Euro
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331,939.0 Euro
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50.0 percent
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17 December 2014
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1 September 2016
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IVI ALICANTE SL
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38°20'37.10"N, 0°29'17.41"W
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03014
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Con este estudio se pretende desarrollar un algoritmo y una estrategia para analizar diversas variables embrionarias, como serían en este caso el estrés oxidativo y el perfil protéico, en un laboratorio de FIV e investigar y validar el uso de ambos como biomarcadores para la viabilidad embrionaria en FIV humano y su uso como marcadores adicionales para la existencia de marcadores morfocinéticos provistos por tecnología secuencial._x000D_ _x000D_ El objetivo de este proyecto es la investigación de nuevos algoritmos de viabilidad embrionaria predictivos y el desarrollo de un sistema y/o herramienta de análisis que incluya las variables de estudio del estrés oxidativo y expresión proteica en cultivos embrionarios adecuados para el uso clínico como marcadores de implantación. Para ello será necesario el desarrollo de nuevas funcionalidades y la validación de la funcionalidad del sistema TCL Analyzer para realizar una mejor selección embrionaria durante el proceso de fecundación in vitro, demostrando su sinergia con los sistemas Time-Lapse. El dispositivo TCL tendrá que tener la sensibilidad necesaria para testear con exactitud pequeñas muestras (10-15 microlitros) de medio. _x000D_ _x000D_ Así como la comparación de los perfiles de expresión proteica del embrión humano utilizando una estrategia basada en proteómica por la que se compararan los medios condicionados de embriones, incubados en Time-Lapse, que implanten frente a aquellos que no, permitiendo desarrollar una herramienta diagnóstica basada en el repertorio proteico diferencial entre ambos tipos de embriones. (Spanish)
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This study aims to develop an algorithm and a strategy to analyse various embryonic variables, such as oxidative stress and the prosthetic profile, in an IVF laboratory and to investigate and validate the use of both as biomarkers for embryonic viability in human IVF and their use as additional markers for the existence of morphokinetic markers provided by sequential technology._x000D_ _x000D_ The objective of this project is to investigate new predictive embryonic viability algorithms and the development of a system or analysis tool that includes the variables of oxidative imaging as a clinical expression. This will require the development of new functionalities and the validation of the functionality of the TCL Analyser system to make a better embryo selection during the in vitro fertilisation process, demonstrating their synergy with Time-Lapse systems. The TCL device must have the sensitivity needed to accurately test small samples (10-15 microlitres) of medium. _x000D_ _x000D_ as well as the comparison of the protein expression profiles of the human embryo using a proteomics-based strategy comparing the conditioned means of embryos, incubated in Time-Lapse, that implant against those who do not, allowing the development of a diagnostic tool based on the differential protein repertoire between both types of embryos. (English)
12 October 2021
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Alicante/Alacant
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Identifiers
IDI-20150110
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