Q3154281 (Q3154281): Difference between revisions
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(Created claim: summary (P836): THE 2015 ALZHEIMER’S GLOBAL REPORT ESTIMATES THAT 46.8 MILLION PEOPLE SUFFER FROM DEMENTIA WORLDWIDE, WITH A FORECAST OF REACHING 131.5 MILLION BY 2050. ALZHEIMER’S DISEASE IS THE MOST COMMON FORM OF DEMENTIA AND CONTRIBUTES IN 60-70 % OF CASES. INTERNATIONALLY, IT IS RECOMMENDED TO FOCUS ACTIONS ON LIGHT COGNITIVE IMPAIRMENT AS A PRECLINIC STATE BECAUSE OF ITS EFFECTIVENESS IN DELAYING DEMENTIA. THE COMBINED STUDY OF HIGH CEREBRAL PRECISION NEU...) |
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THE 2015 ALZHEIMER’S GLOBAL REPORT ESTIMATES THAT 46.8 MILLION PEOPLE SUFFER FROM DEMENTIA WORLDWIDE, WITH A FORECAST OF REACHING 131.5 MILLION BY 2050. ALZHEIMER’S DISEASE IS THE MOST COMMON FORM OF DEMENTIA AND CONTRIBUTES IN 60-70 % OF CASES. INTERNATIONALLY, IT IS RECOMMENDED TO FOCUS ACTIONS ON LIGHT COGNITIVE IMPAIRMENT AS A PRECLINIC STATE BECAUSE OF ITS EFFECTIVENESS IN DELAYING DEMENTIA. THE COMBINED STUDY OF HIGH CEREBRAL PRECISION NEUROIMAGING, COGNITIVE PARAMETERS AND METABOLOMA CONSTITUTE AN OPTIMAL APPROACH THAT WOULD PROVIDE A UNIQUE OPPORTUNITY FOR UNDERSTANDING, PREVENTING AND TREATING DEMENTIA AND PARTICULARLY LIGHT COGNITIVE IMPAIRMENT. THE EFICCOM PROJECT AIMS TO EXAMINE THE EFFECT OF AN INTERVENTION WITH SUPERVISED PHYSICAL EXERCISE OF 5 MONTHS AT THE BRAIN, COGNITIVE AND METABOLOMIC LEVEL IN ELDERLY PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT. SECONDARYLY, THE EFFECT OF THIS INTERVENTION ON ANTIOXIDANT CAPACITY, LIPID AND GLUCOSE METABOLISM, PHYSICAL HEALTH (FUNCTIONAL CAPACITY, ARTERIAL TENSION, BODY COMPOSITION) AND MENTAL (QUALITY OF LIFE AND DEPRESSION), AS WELL AS OTHER RISK FACTORS (GENETIC AND BIOLOGICAL) FOR THE DEVELOPMENT OF ALZHEIMER’S WILL BE STUDIED. A TOTAL OF 100 PEOPLE AGED 65-70 YEARS WITH LIGHT COGNITIVE IMPAIRMENT WERE RANDOMISED IN THE INTERVENTION GROUP WITH SUPERVISED PHYSICAL EXERCISE (N=50) AND THE CONTROL GROUP (N=50). THE DESIGN WILL INCLUDE A 5-MONTH INTERVENTION WITH PRE- AND POST-INTERVENTION MEASUREMENT PHASES AND A THIRD MEASUREMENT (RETEST) AFTER 3 MONTHS OF COMPLETION. THE SUPERVISED PHYSICAL EXERCISE PROGRAM WILL BE OF MUTICOMPONENT TYPE INCLUDING AEROBIC WORK, STRENGTH, COORDINATION-COGNITIVE AND AGILITY-BALANCING, AND WILL ESTABLISH PROGRESSION IN THE DIFFERENT LOAD PARAMETERS (FREQUENCY, VOLUME, INTENSITY, DENSITY). CROSS-SECTIONAL STUDIES HAVE SHOWN EVIDENCE OF A POSITIVE EFFECT OF EXERCISE ON BRAIN AND COGNITIVE PARAMETERS, AND THERE IS NO EVIDENCE OF THE EFFECT AT THE METABOLOMIC LEVEL. THEREFORE, RANDOMLY CONTROLLED STUDIES ARE NECESSARY TO DETERMINE THE SPECIFIC DOSE-RESPONSE EFFECT CONSIDERING THE VARIOUS DIMENSIONS PARALLEL SUCH AS NEUROIMAGE, COGNITIVE STATE AND METABOLOMICA. THIS WILL ALLOW US TO UNDERSTAND FROM A VERY COMPLETE PERSPECTIVE THE CAUSES AND MECHANISMS UNDERLYING SUCH A RESPONSE. THE EFICCOM PROJECT WILL REPRESENT A SIGNIFICANT INCREASE IN SCIENTIFIC KNOWLEDGE ABOUT THE ROLE OF EXERCISE AT THE BRAIN LEVEL AS A THERAPEUTIC MEASURE IN PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT FROM A MULTIDIMENSIONAL PERSPECTIVE. IN ADDITION, THE PROJECT WILL HAVE A SIGNIFICANT IMPACT ON THE SOCIAL AND ECONOMIC LEVEL BY TRANSFERRING THE FINDINGS OF THE STUDY TO THE SOCIAL AND HEALTH FIELD THROUGH THE AGENTS AND MEANS PROVIDED FOR IN THE STUDY. (English) | |||||||||||||||
| Property / summary: THE 2015 ALZHEIMER’S GLOBAL REPORT ESTIMATES THAT 46.8 MILLION PEOPLE SUFFER FROM DEMENTIA WORLDWIDE, WITH A FORECAST OF REACHING 131.5 MILLION BY 2050. ALZHEIMER’S DISEASE IS THE MOST COMMON FORM OF DEMENTIA AND CONTRIBUTES IN 60-70 % OF CASES. INTERNATIONALLY, IT IS RECOMMENDED TO FOCUS ACTIONS ON LIGHT COGNITIVE IMPAIRMENT AS A PRECLINIC STATE BECAUSE OF ITS EFFECTIVENESS IN DELAYING DEMENTIA. THE COMBINED STUDY OF HIGH CEREBRAL PRECISION NEUROIMAGING, COGNITIVE PARAMETERS AND METABOLOMA CONSTITUTE AN OPTIMAL APPROACH THAT WOULD PROVIDE A UNIQUE OPPORTUNITY FOR UNDERSTANDING, PREVENTING AND TREATING DEMENTIA AND PARTICULARLY LIGHT COGNITIVE IMPAIRMENT. THE EFICCOM PROJECT AIMS TO EXAMINE THE EFFECT OF AN INTERVENTION WITH SUPERVISED PHYSICAL EXERCISE OF 5 MONTHS AT THE BRAIN, COGNITIVE AND METABOLOMIC LEVEL IN ELDERLY PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT. SECONDARYLY, THE EFFECT OF THIS INTERVENTION ON ANTIOXIDANT CAPACITY, LIPID AND GLUCOSE METABOLISM, PHYSICAL HEALTH (FUNCTIONAL CAPACITY, ARTERIAL TENSION, BODY COMPOSITION) AND MENTAL (QUALITY OF LIFE AND DEPRESSION), AS WELL AS OTHER RISK FACTORS (GENETIC AND BIOLOGICAL) FOR THE DEVELOPMENT OF ALZHEIMER’S WILL BE STUDIED. A TOTAL OF 100 PEOPLE AGED 65-70 YEARS WITH LIGHT COGNITIVE IMPAIRMENT WERE RANDOMISED IN THE INTERVENTION GROUP WITH SUPERVISED PHYSICAL EXERCISE (N=50) AND THE CONTROL GROUP (N=50). THE DESIGN WILL INCLUDE A 5-MONTH INTERVENTION WITH PRE- AND POST-INTERVENTION MEASUREMENT PHASES AND A THIRD MEASUREMENT (RETEST) AFTER 3 MONTHS OF COMPLETION. THE SUPERVISED PHYSICAL EXERCISE PROGRAM WILL BE OF MUTICOMPONENT TYPE INCLUDING AEROBIC WORK, STRENGTH, COORDINATION-COGNITIVE AND AGILITY-BALANCING, AND WILL ESTABLISH PROGRESSION IN THE DIFFERENT LOAD PARAMETERS (FREQUENCY, VOLUME, INTENSITY, DENSITY). CROSS-SECTIONAL STUDIES HAVE SHOWN EVIDENCE OF A POSITIVE EFFECT OF EXERCISE ON BRAIN AND COGNITIVE PARAMETERS, AND THERE IS NO EVIDENCE OF THE EFFECT AT THE METABOLOMIC LEVEL. THEREFORE, RANDOMLY CONTROLLED STUDIES ARE NECESSARY TO DETERMINE THE SPECIFIC DOSE-RESPONSE EFFECT CONSIDERING THE VARIOUS DIMENSIONS PARALLEL SUCH AS NEUROIMAGE, COGNITIVE STATE AND METABOLOMICA. THIS WILL ALLOW US TO UNDERSTAND FROM A VERY COMPLETE PERSPECTIVE THE CAUSES AND MECHANISMS UNDERLYING SUCH A RESPONSE. THE EFICCOM PROJECT WILL REPRESENT A SIGNIFICANT INCREASE IN SCIENTIFIC KNOWLEDGE ABOUT THE ROLE OF EXERCISE AT THE BRAIN LEVEL AS A THERAPEUTIC MEASURE IN PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT FROM A MULTIDIMENSIONAL PERSPECTIVE. IN ADDITION, THE PROJECT WILL HAVE A SIGNIFICANT IMPACT ON THE SOCIAL AND ECONOMIC LEVEL BY TRANSFERRING THE FINDINGS OF THE STUDY TO THE SOCIAL AND HEALTH FIELD THROUGH THE AGENTS AND MEANS PROVIDED FOR IN THE STUDY. (English) / rank | |||||||||||||||
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| Property / summary: THE 2015 ALZHEIMER’S GLOBAL REPORT ESTIMATES THAT 46.8 MILLION PEOPLE SUFFER FROM DEMENTIA WORLDWIDE, WITH A FORECAST OF REACHING 131.5 MILLION BY 2050. ALZHEIMER’S DISEASE IS THE MOST COMMON FORM OF DEMENTIA AND CONTRIBUTES IN 60-70 % OF CASES. INTERNATIONALLY, IT IS RECOMMENDED TO FOCUS ACTIONS ON LIGHT COGNITIVE IMPAIRMENT AS A PRECLINIC STATE BECAUSE OF ITS EFFECTIVENESS IN DELAYING DEMENTIA. THE COMBINED STUDY OF HIGH CEREBRAL PRECISION NEUROIMAGING, COGNITIVE PARAMETERS AND METABOLOMA CONSTITUTE AN OPTIMAL APPROACH THAT WOULD PROVIDE A UNIQUE OPPORTUNITY FOR UNDERSTANDING, PREVENTING AND TREATING DEMENTIA AND PARTICULARLY LIGHT COGNITIVE IMPAIRMENT. THE EFICCOM PROJECT AIMS TO EXAMINE THE EFFECT OF AN INTERVENTION WITH SUPERVISED PHYSICAL EXERCISE OF 5 MONTHS AT THE BRAIN, COGNITIVE AND METABOLOMIC LEVEL IN ELDERLY PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT. SECONDARYLY, THE EFFECT OF THIS INTERVENTION ON ANTIOXIDANT CAPACITY, LIPID AND GLUCOSE METABOLISM, PHYSICAL HEALTH (FUNCTIONAL CAPACITY, ARTERIAL TENSION, BODY COMPOSITION) AND MENTAL (QUALITY OF LIFE AND DEPRESSION), AS WELL AS OTHER RISK FACTORS (GENETIC AND BIOLOGICAL) FOR THE DEVELOPMENT OF ALZHEIMER’S WILL BE STUDIED. A TOTAL OF 100 PEOPLE AGED 65-70 YEARS WITH LIGHT COGNITIVE IMPAIRMENT WERE RANDOMISED IN THE INTERVENTION GROUP WITH SUPERVISED PHYSICAL EXERCISE (N=50) AND THE CONTROL GROUP (N=50). THE DESIGN WILL INCLUDE A 5-MONTH INTERVENTION WITH PRE- AND POST-INTERVENTION MEASUREMENT PHASES AND A THIRD MEASUREMENT (RETEST) AFTER 3 MONTHS OF COMPLETION. THE SUPERVISED PHYSICAL EXERCISE PROGRAM WILL BE OF MUTICOMPONENT TYPE INCLUDING AEROBIC WORK, STRENGTH, COORDINATION-COGNITIVE AND AGILITY-BALANCING, AND WILL ESTABLISH PROGRESSION IN THE DIFFERENT LOAD PARAMETERS (FREQUENCY, VOLUME, INTENSITY, DENSITY). CROSS-SECTIONAL STUDIES HAVE SHOWN EVIDENCE OF A POSITIVE EFFECT OF EXERCISE ON BRAIN AND COGNITIVE PARAMETERS, AND THERE IS NO EVIDENCE OF THE EFFECT AT THE METABOLOMIC LEVEL. THEREFORE, RANDOMLY CONTROLLED STUDIES ARE NECESSARY TO DETERMINE THE SPECIFIC DOSE-RESPONSE EFFECT CONSIDERING THE VARIOUS DIMENSIONS PARALLEL SUCH AS NEUROIMAGE, COGNITIVE STATE AND METABOLOMICA. THIS WILL ALLOW US TO UNDERSTAND FROM A VERY COMPLETE PERSPECTIVE THE CAUSES AND MECHANISMS UNDERLYING SUCH A RESPONSE. THE EFICCOM PROJECT WILL REPRESENT A SIGNIFICANT INCREASE IN SCIENTIFIC KNOWLEDGE ABOUT THE ROLE OF EXERCISE AT THE BRAIN LEVEL AS A THERAPEUTIC MEASURE IN PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT FROM A MULTIDIMENSIONAL PERSPECTIVE. IN ADDITION, THE PROJECT WILL HAVE A SIGNIFICANT IMPACT ON THE SOCIAL AND ECONOMIC LEVEL BY TRANSFERRING THE FINDINGS OF THE STUDY TO THE SOCIAL AND HEALTH FIELD THROUGH THE AGENTS AND MEANS PROVIDED FOR IN THE STUDY. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:35, 12 October 2021
Project Q3154281 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3154281 in Spain |
Statements
96,800.0 Euro
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121,000.0 Euro
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80.0 percent
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30 December 2016
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29 December 2020
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UNIVERSIDAD DE CADIZ
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36°31'43.28"N, 6°11'24.79"W
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11028
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EL INFORME MUNDIAL DE ALZHEIMER DE 2015 ESTIMA QUE 46,8 MILLONES DE PERSONAS SUFREN DEMENCIA EN TODO EL MUNDO, CON LA PREVISION DE QUE ALCANCE LOS 131,5 MILLONES EN 2050. LA ENFERMEDAD DE ALZHEIMER ES LA FORMA MAS COMUN DE DEMENCIA Y CONTRIBUYE EN UN 60-70% DE LOS CASOS. INTERNACIONALMENTE SE RECOMIENDA CENTRAR LAS ACTUACIONES EN EL DETERIORO COGNITIVO LIGERO COMO ESTADO PRECLINICO POR SU EFICACIA PARA RETRASAR LA DEMENCIA. EL ESTUDIO COMBINADO DE NEUROIMAGEN DE ALTA PRECISION CEREBRAL, PARAMETROS COGNITIVOS Y DEL METABOLOMA CONSTITUYEN UN ENFOQUE OPTIMO QUE PROPORCIONARIA UNA OPORTUNIDAD UNICA PARA EL ENTENDIMIENTO, PREVENCION Y TRATAMIENTO DE LA DEMENCIA Y EN PARTICULAR DEL DETERIORO COGNITIVO LIGERO. EL PROYECTO EFICCOM PRETENDE EXAMINAR EL EFECTO DE UNA INTERVENCION CON EJERCICIO FISICO SUPERVISADO DE 5 MESES A NIVEL CEREBRAL, COGNITIVO, METABOLOMICO EN PERSONAS MAYORES CON DETERIORO COGNITIVO LIGERO. DE FORMA SECUNDARIA, SE ESTUDIARA EL EFECTO DE ESTA INTERVENCION SOBRE LA CAPACIDAD ANTIOXIDANTE, EL METABOLISMO DE LIPIDOS Y GLUCOSA, SALUD FISICA (CAPACIDAD FUNCIONAL, TENSION ARTERIAL, COMPOSICION CORPORAL) Y MENTAL (CALIDAD DE VIDA Y DEPRESION), ASI COMO SOBRE OTROS FACTORES DE RIESGO (GENETICOS Y BIOLOGICOS) PARA EL DESARROLLO DE ALZHEIMER. UN TOTAL DE 100 PERSONAS MAYORES DE ENTRE 65 Y 70 AÑOS DE EDAD CON DETERIORO COGNITIVO LIGERO SE DISTRIBUIRAN DE FORMA RANDOMIZADA EN EL GRUPO DE INTERVENCION CON EJERCICIO FISICO SUPERVISADO (N=50) Y EL GRUPO CONTROL (N=50). EL DISEÑO INCLUIRA UNA INTERVENCION DE 5 MESES CON FASES DE MEDICION PRE Y POST INTERVENCION Y UNA TERCERA MEDICION (RETEST) PASADOS 3 MESES DE LA FINALIZACION. EL PROGRAMA DE EJERICICIO FISICO SUPERVISADO SERA DE TIPO MUTICOMPONENTE INCLUYENDO TRABAJO AEROBICO, FUERZA, COORDINATIVO-COGNITIVO Y AGILIDAD-EQUILIBRIO, Y SE ESTABLECERA UNA PROGRESION EN LOS DIFERENTES PARAMETROS DE CARGA (FRECUENCIA, VOLUMEN, INTENSIDAD, DENSIDAD). ESTUDIOS A NIVEL TRANSVERSAL HAN MOSTRADO EVIDENCIAS DE UN EFECTO POSITIVO DEL EJERCICIO SOBRE PARAMETROS CEREBRALES Y COGNITIVOS, NO EXISTIENDO EVIDENCIA DEL EFECTO A NIVEL METABOLOMICO. POR ELLO, SON NECESARIOS ESTUDIOS CONTROLADOS DE FORMA ALEATORIA PARA CONOCER EL EFECTO ESPECIFICO DE DOSIS-RESPUESTA CONSIDERANDO LA DIVERSAS DIMENSIONES PARALELAMENTE COMO SON NEUROIMAGEN, ESTADO COGNITIVO Y METABOLOMICA. ESTO NOS PERMITIRA ENTENDER DESDE UNA PERSPECTIVA MUY COMPLETA LAS CAUSAS Y MECANISMOS SUBYACENTES A DICHA RESPUESTA. EL PROYECTO EFICCOM SUPONDRA UN INCREMENTO SIGNIFICATIVO EN EL CONOCIMIENTO CIENTIFICO SOBRE EL PAPEL DEL EJERCICIO A NIVEL CEREBRAL COMO MEDIDA TERAPEUTICA EN PERSONAS CON DETERIORO COGNITIVO LIGERO DESDE UNA PERSPECTIVA MULTIDIMENSIONAL. ADEMAS EL PROYECTO TENDRA UNA RELEVANTE REPERCUSION A NIVEL SOCIAL Y ECONOMICO MEDIANTE LA TRANSFERENCIA DE LOS HALLAZGOS DEL ESTUDIO AL AMBITO SOCIAL Y SANITARIO MEDIANTE LOS AGENTES Y MEDIOS PREVISTOS EN EL MISMO (Spanish)
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THE 2015 ALZHEIMER’S GLOBAL REPORT ESTIMATES THAT 46.8 MILLION PEOPLE SUFFER FROM DEMENTIA WORLDWIDE, WITH A FORECAST OF REACHING 131.5 MILLION BY 2050. ALZHEIMER’S DISEASE IS THE MOST COMMON FORM OF DEMENTIA AND CONTRIBUTES IN 60-70 % OF CASES. INTERNATIONALLY, IT IS RECOMMENDED TO FOCUS ACTIONS ON LIGHT COGNITIVE IMPAIRMENT AS A PRECLINIC STATE BECAUSE OF ITS EFFECTIVENESS IN DELAYING DEMENTIA. THE COMBINED STUDY OF HIGH CEREBRAL PRECISION NEUROIMAGING, COGNITIVE PARAMETERS AND METABOLOMA CONSTITUTE AN OPTIMAL APPROACH THAT WOULD PROVIDE A UNIQUE OPPORTUNITY FOR UNDERSTANDING, PREVENTING AND TREATING DEMENTIA AND PARTICULARLY LIGHT COGNITIVE IMPAIRMENT. THE EFICCOM PROJECT AIMS TO EXAMINE THE EFFECT OF AN INTERVENTION WITH SUPERVISED PHYSICAL EXERCISE OF 5 MONTHS AT THE BRAIN, COGNITIVE AND METABOLOMIC LEVEL IN ELDERLY PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT. SECONDARYLY, THE EFFECT OF THIS INTERVENTION ON ANTIOXIDANT CAPACITY, LIPID AND GLUCOSE METABOLISM, PHYSICAL HEALTH (FUNCTIONAL CAPACITY, ARTERIAL TENSION, BODY COMPOSITION) AND MENTAL (QUALITY OF LIFE AND DEPRESSION), AS WELL AS OTHER RISK FACTORS (GENETIC AND BIOLOGICAL) FOR THE DEVELOPMENT OF ALZHEIMER’S WILL BE STUDIED. A TOTAL OF 100 PEOPLE AGED 65-70 YEARS WITH LIGHT COGNITIVE IMPAIRMENT WERE RANDOMISED IN THE INTERVENTION GROUP WITH SUPERVISED PHYSICAL EXERCISE (N=50) AND THE CONTROL GROUP (N=50). THE DESIGN WILL INCLUDE A 5-MONTH INTERVENTION WITH PRE- AND POST-INTERVENTION MEASUREMENT PHASES AND A THIRD MEASUREMENT (RETEST) AFTER 3 MONTHS OF COMPLETION. THE SUPERVISED PHYSICAL EXERCISE PROGRAM WILL BE OF MUTICOMPONENT TYPE INCLUDING AEROBIC WORK, STRENGTH, COORDINATION-COGNITIVE AND AGILITY-BALANCING, AND WILL ESTABLISH PROGRESSION IN THE DIFFERENT LOAD PARAMETERS (FREQUENCY, VOLUME, INTENSITY, DENSITY). CROSS-SECTIONAL STUDIES HAVE SHOWN EVIDENCE OF A POSITIVE EFFECT OF EXERCISE ON BRAIN AND COGNITIVE PARAMETERS, AND THERE IS NO EVIDENCE OF THE EFFECT AT THE METABOLOMIC LEVEL. THEREFORE, RANDOMLY CONTROLLED STUDIES ARE NECESSARY TO DETERMINE THE SPECIFIC DOSE-RESPONSE EFFECT CONSIDERING THE VARIOUS DIMENSIONS PARALLEL SUCH AS NEUROIMAGE, COGNITIVE STATE AND METABOLOMICA. THIS WILL ALLOW US TO UNDERSTAND FROM A VERY COMPLETE PERSPECTIVE THE CAUSES AND MECHANISMS UNDERLYING SUCH A RESPONSE. THE EFICCOM PROJECT WILL REPRESENT A SIGNIFICANT INCREASE IN SCIENTIFIC KNOWLEDGE ABOUT THE ROLE OF EXERCISE AT THE BRAIN LEVEL AS A THERAPEUTIC MEASURE IN PEOPLE WITH LIGHT COGNITIVE IMPAIRMENT FROM A MULTIDIMENSIONAL PERSPECTIVE. IN ADDITION, THE PROJECT WILL HAVE A SIGNIFICANT IMPACT ON THE SOCIAL AND ECONOMIC LEVEL BY TRANSFERRING THE FINDINGS OF THE STUDY TO THE SOCIAL AND HEALTH FIELD THROUGH THE AGENTS AND MEANS PROVIDED FOR IN THE STUDY. (English)
12 October 2021
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Puerto Real
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Identifiers
DEP2016-76123-R
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