Q3156852 (Q3156852): Difference between revisions
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(Created claim: summary (P836): EUKARYOTIC CELLS ARE CONTINUOUSLY PRODUCING AND SECRETING PROTEINS, SUCH AS INSULIN, CHOLAGENE AND NEUROTRANSMITTERS. THESE PROTEINS ARE TRANSPORTED ALONG THE SECRETORY ROUTE AND ITS DIFFERENT ORGANULOS. IN PARTICULAR, THEY ARE TRANSPORTED THROUGH THE GOLGI COMPLEX, WHERE THESE PROTEINS ARE PROCESSED, DISTRIBUTED AND EVENTUALLY EXPORTED. Failures in these processes can have NOCIVE CONSEQUENCES that can cause serious damage, as many as several ne...) |
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EUKARYOTIC CELLS ARE CONTINUOUSLY PRODUCING AND SECRETING PROTEINS, SUCH AS INSULIN, CHOLAGENE AND NEUROTRANSMITTERS. THESE PROTEINS ARE TRANSPORTED ALONG THE SECRETORY ROUTE AND ITS DIFFERENT ORGANULOS. IN PARTICULAR, THEY ARE TRANSPORTED THROUGH THE GOLGI COMPLEX, WHERE THESE PROTEINS ARE PROCESSED, DISTRIBUTED AND EVENTUALLY EXPORTED. Failures in these processes can have NOCIVE CONSEQUENCES that can cause serious damage, as many as several negative and immunological, diabetic, or congenital defects of GLICOSIlation._x000D_ WEIGHT OF THE GLICOSILACE the status of GOLGI MEMBRANS WITH CONVENTIONAL MICROSCOPY TOOLS has been an all-challenge, due to its DINAMIC nature and its small size. For this reason, there are many years of research in this camp, we do not yet settle with CLARITY as the products are transported to the length of the discrepancies of the GOLGI COMPLEMENT._x000D_ The main product of this project is the one to unravel the mechanisms of FUNCIONAL ORGANISATION OF GOLGI MEMBRANES. IN PARTICULAR, WE WILL INVESTIGATE THE MECHANISMS BY WHICH THE SECRETORY PROTEINS ARE PROCESSED AND TRANSPORTED THROUGH THE GOLGI COMPLEX AND HOW THESE MEMBRANES ARE COMPARTMENTALISED IN A FUNCTIONAL WAY. Finally, we hope that we can get to buy better the mechanisms that underlie the diseases related to the very functioning of the GOLGI COMPLEMENT._x000D_ to overwhelm the risks of this project, we use a new MULTIDISCIPLINAL BIOLOGY TOOLS TOOLS OF MOLECULAR AND CELL BIOLOGY, super-resolution nanoscopy and biophysic modelling. WE WILL FOCUS ON THREE MAIN OBJECTIVES: (1) TO ELUCIDATE THE CONTENTS OF THE INTRA-GOLGI TRANSPORT VESICLES; (2) STUDY THE LATERAL COMPARTMENTALISATION OF GOLGI MEMBRANES; And (3) DEVELOPING A QUANTITATIVE biophysical model of the intra-GOLGI TRAFIC based on our EXPERIMENTAL RESULTS._x000D_ THE NEWS OF THIS PROPOSES CONSISTE IN ASPECTS: PROVIDE CLEAR EXPERIMENTAL RESULTS ON THE CONTENT AND DIRECTIONALITY OF INTRA-GOLGI TRANSPORT VESICLES; THE USE OF SUPER-RESOLUTION NANOSCOPY TECHNIQUES TO STUDY THE LATERAL ORGANISATION OF GOLGI MEMBRANES; AND C) COMBINE ALL THIS INFORMATION TO PROPOSE AND CHARACTERISE IN A BIOPHYSICAL WAY A CONSENSUS MODEL FOR INTRA-GOLGI MEMBRANE TRAFFIC. THIS PROJECT IS FULLY ALIGNED WITH THE SOCIETAL CHALLENGE OF THE HORIZON 2020 PROGRAMME OF “HEALTH, DEMOGRAPHIC CHANGE AND WELL-BEING”, AS WE HOPE THAT OUR RESULTS WILL IMPROVE OUR UNDERSTANDING OF THE MECHANISMS RESPONSIBLE FOR DISEASES. In addition, one of the primary enabling technologies to be used is the super-resolution nanoscopy, included in the PHOTONIC, one of the “KEY Enabling TECHNOLOGIES” (KET) of the EC-H2020 programme._x000D_ in summary, we foresee that the results of this project will have a high impact on our vision of a fundamental part of the CELULAR BIOLOGY. IN PARTICULAR, WE HOPE THAT OUR RESULTS WILL BE HELPFUL IN DESIGNING NEW THERAPEUTIC OPTIONS AND TRACKING COMPOUNDS TO REVERSE THE PATHOLOGICAL EFFECTS OF VARIOUS DISEASES RELATED TO THE MALFUNCTION OF THE GOLGI COMPLEX. (English) | |||||||||||||||
| Property / summary: EUKARYOTIC CELLS ARE CONTINUOUSLY PRODUCING AND SECRETING PROTEINS, SUCH AS INSULIN, CHOLAGENE AND NEUROTRANSMITTERS. THESE PROTEINS ARE TRANSPORTED ALONG THE SECRETORY ROUTE AND ITS DIFFERENT ORGANULOS. IN PARTICULAR, THEY ARE TRANSPORTED THROUGH THE GOLGI COMPLEX, WHERE THESE PROTEINS ARE PROCESSED, DISTRIBUTED AND EVENTUALLY EXPORTED. Failures in these processes can have NOCIVE CONSEQUENCES that can cause serious damage, as many as several negative and immunological, diabetic, or congenital defects of GLICOSIlation._x000D_ WEIGHT OF THE GLICOSILACE the status of GOLGI MEMBRANS WITH CONVENTIONAL MICROSCOPY TOOLS has been an all-challenge, due to its DINAMIC nature and its small size. For this reason, there are many years of research in this camp, we do not yet settle with CLARITY as the products are transported to the length of the discrepancies of the GOLGI COMPLEMENT._x000D_ The main product of this project is the one to unravel the mechanisms of FUNCIONAL ORGANISATION OF GOLGI MEMBRANES. IN PARTICULAR, WE WILL INVESTIGATE THE MECHANISMS BY WHICH THE SECRETORY PROTEINS ARE PROCESSED AND TRANSPORTED THROUGH THE GOLGI COMPLEX AND HOW THESE MEMBRANES ARE COMPARTMENTALISED IN A FUNCTIONAL WAY. Finally, we hope that we can get to buy better the mechanisms that underlie the diseases related to the very functioning of the GOLGI COMPLEMENT._x000D_ to overwhelm the risks of this project, we use a new MULTIDISCIPLINAL BIOLOGY TOOLS TOOLS OF MOLECULAR AND CELL BIOLOGY, super-resolution nanoscopy and biophysic modelling. WE WILL FOCUS ON THREE MAIN OBJECTIVES: (1) TO ELUCIDATE THE CONTENTS OF THE INTRA-GOLGI TRANSPORT VESICLES; (2) STUDY THE LATERAL COMPARTMENTALISATION OF GOLGI MEMBRANES; And (3) DEVELOPING A QUANTITATIVE biophysical model of the intra-GOLGI TRAFIC based on our EXPERIMENTAL RESULTS._x000D_ THE NEWS OF THIS PROPOSES CONSISTE IN ASPECTS: PROVIDE CLEAR EXPERIMENTAL RESULTS ON THE CONTENT AND DIRECTIONALITY OF INTRA-GOLGI TRANSPORT VESICLES; THE USE OF SUPER-RESOLUTION NANOSCOPY TECHNIQUES TO STUDY THE LATERAL ORGANISATION OF GOLGI MEMBRANES; AND C) COMBINE ALL THIS INFORMATION TO PROPOSE AND CHARACTERISE IN A BIOPHYSICAL WAY A CONSENSUS MODEL FOR INTRA-GOLGI MEMBRANE TRAFFIC. THIS PROJECT IS FULLY ALIGNED WITH THE SOCIETAL CHALLENGE OF THE HORIZON 2020 PROGRAMME OF “HEALTH, DEMOGRAPHIC CHANGE AND WELL-BEING”, AS WE HOPE THAT OUR RESULTS WILL IMPROVE OUR UNDERSTANDING OF THE MECHANISMS RESPONSIBLE FOR DISEASES. In addition, one of the primary enabling technologies to be used is the super-resolution nanoscopy, included in the PHOTONIC, one of the “KEY Enabling TECHNOLOGIES” (KET) of the EC-H2020 programme._x000D_ in summary, we foresee that the results of this project will have a high impact on our vision of a fundamental part of the CELULAR BIOLOGY. IN PARTICULAR, WE HOPE THAT OUR RESULTS WILL BE HELPFUL IN DESIGNING NEW THERAPEUTIC OPTIONS AND TRACKING COMPOUNDS TO REVERSE THE PATHOLOGICAL EFFECTS OF VARIOUS DISEASES RELATED TO THE MALFUNCTION OF THE GOLGI COMPLEX. (English) / rank | |||||||||||||||
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| Property / summary: EUKARYOTIC CELLS ARE CONTINUOUSLY PRODUCING AND SECRETING PROTEINS, SUCH AS INSULIN, CHOLAGENE AND NEUROTRANSMITTERS. THESE PROTEINS ARE TRANSPORTED ALONG THE SECRETORY ROUTE AND ITS DIFFERENT ORGANULOS. IN PARTICULAR, THEY ARE TRANSPORTED THROUGH THE GOLGI COMPLEX, WHERE THESE PROTEINS ARE PROCESSED, DISTRIBUTED AND EVENTUALLY EXPORTED. Failures in these processes can have NOCIVE CONSEQUENCES that can cause serious damage, as many as several negative and immunological, diabetic, or congenital defects of GLICOSIlation._x000D_ WEIGHT OF THE GLICOSILACE the status of GOLGI MEMBRANS WITH CONVENTIONAL MICROSCOPY TOOLS has been an all-challenge, due to its DINAMIC nature and its small size. For this reason, there are many years of research in this camp, we do not yet settle with CLARITY as the products are transported to the length of the discrepancies of the GOLGI COMPLEMENT._x000D_ The main product of this project is the one to unravel the mechanisms of FUNCIONAL ORGANISATION OF GOLGI MEMBRANES. IN PARTICULAR, WE WILL INVESTIGATE THE MECHANISMS BY WHICH THE SECRETORY PROTEINS ARE PROCESSED AND TRANSPORTED THROUGH THE GOLGI COMPLEX AND HOW THESE MEMBRANES ARE COMPARTMENTALISED IN A FUNCTIONAL WAY. Finally, we hope that we can get to buy better the mechanisms that underlie the diseases related to the very functioning of the GOLGI COMPLEMENT._x000D_ to overwhelm the risks of this project, we use a new MULTIDISCIPLINAL BIOLOGY TOOLS TOOLS OF MOLECULAR AND CELL BIOLOGY, super-resolution nanoscopy and biophysic modelling. WE WILL FOCUS ON THREE MAIN OBJECTIVES: (1) TO ELUCIDATE THE CONTENTS OF THE INTRA-GOLGI TRANSPORT VESICLES; (2) STUDY THE LATERAL COMPARTMENTALISATION OF GOLGI MEMBRANES; And (3) DEVELOPING A QUANTITATIVE biophysical model of the intra-GOLGI TRAFIC based on our EXPERIMENTAL RESULTS._x000D_ THE NEWS OF THIS PROPOSES CONSISTE IN ASPECTS: PROVIDE CLEAR EXPERIMENTAL RESULTS ON THE CONTENT AND DIRECTIONALITY OF INTRA-GOLGI TRANSPORT VESICLES; THE USE OF SUPER-RESOLUTION NANOSCOPY TECHNIQUES TO STUDY THE LATERAL ORGANISATION OF GOLGI MEMBRANES; AND C) COMBINE ALL THIS INFORMATION TO PROPOSE AND CHARACTERISE IN A BIOPHYSICAL WAY A CONSENSUS MODEL FOR INTRA-GOLGI MEMBRANE TRAFFIC. THIS PROJECT IS FULLY ALIGNED WITH THE SOCIETAL CHALLENGE OF THE HORIZON 2020 PROGRAMME OF “HEALTH, DEMOGRAPHIC CHANGE AND WELL-BEING”, AS WE HOPE THAT OUR RESULTS WILL IMPROVE OUR UNDERSTANDING OF THE MECHANISMS RESPONSIBLE FOR DISEASES. In addition, one of the primary enabling technologies to be used is the super-resolution nanoscopy, included in the PHOTONIC, one of the “KEY Enabling TECHNOLOGIES” (KET) of the EC-H2020 programme._x000D_ in summary, we foresee that the results of this project will have a high impact on our vision of a fundamental part of the CELULAR BIOLOGY. IN PARTICULAR, WE HOPE THAT OUR RESULTS WILL BE HELPFUL IN DESIGNING NEW THERAPEUTIC OPTIONS AND TRACKING COMPOUNDS TO REVERSE THE PATHOLOGICAL EFFECTS OF VARIOUS DISEASES RELATED TO THE MALFUNCTION OF THE GOLGI COMPLEX. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 15:28, 12 October 2021
Project Q3156852 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3156852 in Spain |
Statements
102,850.0 Euro
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205,700.0 Euro
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50.0 percent
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1 February 2017
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31 January 2020
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INSTITUTO DE CIENCIAS FOTONICAS
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41°17'9.96"N, 1°58'56.71"E
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08056
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LAS CELULAS EUCARIOTAS ESTAN CONTINUAMENTE PRODUCIENDO Y SECRETANDO PROTEINAS, TALES COMO LA INSULINA, EL COLAGENO Y LOS NEUROTRANSMISORES. ESTAS PROTEINAS SON TRANSPORTADAS A LO LARGO DE LA RUTA SECRETORA Y DE SUS DIFERENTES ORGANULOS. EN PARTICULAR, SE TRANSPORTAN A TRAVES DEL COMPLEJO DE GOLGI, DONDE ESTAS PROTEINAS SE PROCESAN, SE DISTRIBUYEN Y FINALMENTE SE EXPORTAN. FALLOS EN ESTOS PROCESOS PUEDEN TENER CONSECUENCIAS NOCIVAS QUE PUEDEN CAUSAR GRAVES ENFERMEDADES, TALES COMO VARIOS DESORDENES NEUROLOGICOS E INMUNOLOGICOS, DIABETES O DEFECTOS CONGENITOS DE LA GLICOSILACION._x000D_ A PESAR DE LA GRAN IMPORTANCIA QUE TIENE, EL ESTUDIO LAS MEMBRANAS DE GOLGI CON HERRAMIENTAS DE MICROSCOPIA CONVENCIONAL HA SIDO TODO UN RETO, DEBIDO A SU NATURALEZA DINAMICA Y A SU PEQUEÑO TAMAÑO. POR ESTO, DESPUES DE MUCHOS AÑOS DE INVESTIGACION EN ESTE CAMPO, AUN NO ENTENDEMOS CON CLARIDAD COMO SE TRANSPORTAN LAS PROTEINAS A LO LARGO DE LAS DIFERENTES MEMBRANAS DEL COMPLEJO DE GOLGI._x000D_ EL PROPOSITO PRINCIPAL DE ESTE PROYECTO ES EL DE DESENMARAÑAR LOS MECANISMOS DE ORGANIZACION FUNCIONAL DE LAS MEMBRANAS DE GOLGI. EN CONCRETO, INVESTIGAREMOS LOS MECANISMOS POR LOS CUALES LAS PROTEINAS SECRETORAS SE PROCESAN Y TRANSPORTAN A TRAVES DEL COMPLEJO DE GOLGI Y COMO ESTAS MEMBRANAS SE COMPARTIMENTAN DE MANERA FUNCIONAL. FINALMENTE, ESPERAMOS PODER LLEGAR A COMPRENDER MEJOR LOS MECANISMOS QUE SUBYACEN A ENFERMEDADES RELACIONADAS CON EL MAL FUNCIONAMIENTO DEL COMPLEJO DE GOLGI._x000D_ PARA ABORDAR LOS RETOS DE ESTE AMBICIOSO PROYECTO, USAREMOS UN NUEVO ENFOQUE MULTIDISCIPLINAR QUE COMBINA HERRAMIENTAS AVANZADAS DE BIOLOGIA MOLECULAR Y CELULAR, NANOSCOPIA DE SUPER-RESOLUCION Y MODELIZACION BIOFISICA. NOS CENTRAREMOS EN TRES OBJETIVOS PRINCIPALES: (1) DILUCIDAR EL CONTENIDO DE LAS VESICULAS DE TRANSPORTE INTRA-GOLGI; (2) ESTUDIAR LA COMPARTIMENTALIZACION LATERAL DE LAS MEMBRANAS DE GOLGI; Y (3) DESARROLLAR UN MODELO BIOFISICO CUANTITATIVO DEL TRAFICO INTRA-GOLGI BASADO EN NUESTROS RESULTADOS EXPERIMENTALES._x000D_ LA NOVEDAD DE ESTA PROPUESTA CONSISTE EN VARIOS ASPECTOS: A) APORTAR RESULTADOS EXPERIMENTALES CLAROS SOBRE EL CONTENIDO Y LA DIRECCIONALIDAD DE LAS VESICULAS DE TRANSPORTE INTRA-GOLGI; B) EL USO DE TECNICAS DE NANOSCOPIA DE SUPER-RESOLUCION PARA ESTUDIAR LA ORGANIZACION LATERAL DE LAS MEMBRANAS DE GOLGI; Y C) COMBINAR TODA ESTA INFORMACION PARA PROPONER Y CARACTERIZAR DE MANERA BIOFISICA UN MODELO DE CONSENSO PARA EL TRAFICO DE MEMBRANAS INTRA-GOLGI. ESTE PROYECTO ESTA PLENAMENTE ALINEADO CON EL RETO DE LA SOCIEDAD DEL PROGRAMA HORIZON 2020 DE "SALUD, CAMBIO DEMOGRAFICO Y BIENESTAR", DADO QUE ESPERAMOS QUE NUESTROS RESULTADOS VAYAN A MEJORAR NUESTRA COMPRENSION DE LOS MECANISMOS RESPONSABLES DE ENFERMEDADES. ADEMAS, UNA DE LAS PRINCIPALES TECNOLOGIAS FACILITADORAS QUE SE USARA ES LA NANOSCOPIA DE SUPER-RESOLUCION, ENGLOBADA EN LA FOTONICA, UNA DE LAS "KEY ENABLING TECHNOLOGIES" (KET) DEL PROGRAMA EC-H2020._x000D_ EN RESUMEN, PREVEMOS QUE LOS RESULTADOS DE ESTE PROYECTO VAN A TENER UN ALTO IMPACTO EN NUESTRA VISION DE UNA PARTE FUNDAMENTAL DE LA BIOLOGIA CELULAR. EN CONCRETO, ESPERAMOS QUE NUESTROS RESULTADOS SEAN DE AYUDA PARA EL DISEÑO DE NUEVAS OPCIONES TERAPEUTICAS Y DE RASTREO DE COMPUESTOS PARA REVERTIR LOS EFECTOS PATOLOGICOS DE VARIAS ENFERMEDADES RELACIONADAS CON EL MAL FUNCIONAMIENTO DEL COMPLEJO DE GOLGI. (Spanish)
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EUKARYOTIC CELLS ARE CONTINUOUSLY PRODUCING AND SECRETING PROTEINS, SUCH AS INSULIN, CHOLAGENE AND NEUROTRANSMITTERS. THESE PROTEINS ARE TRANSPORTED ALONG THE SECRETORY ROUTE AND ITS DIFFERENT ORGANULOS. IN PARTICULAR, THEY ARE TRANSPORTED THROUGH THE GOLGI COMPLEX, WHERE THESE PROTEINS ARE PROCESSED, DISTRIBUTED AND EVENTUALLY EXPORTED. Failures in these processes can have NOCIVE CONSEQUENCES that can cause serious damage, as many as several negative and immunological, diabetic, or congenital defects of GLICOSIlation._x000D_ WEIGHT OF THE GLICOSILACE the status of GOLGI MEMBRANS WITH CONVENTIONAL MICROSCOPY TOOLS has been an all-challenge, due to its DINAMIC nature and its small size. For this reason, there are many years of research in this camp, we do not yet settle with CLARITY as the products are transported to the length of the discrepancies of the GOLGI COMPLEMENT._x000D_ The main product of this project is the one to unravel the mechanisms of FUNCIONAL ORGANISATION OF GOLGI MEMBRANES. IN PARTICULAR, WE WILL INVESTIGATE THE MECHANISMS BY WHICH THE SECRETORY PROTEINS ARE PROCESSED AND TRANSPORTED THROUGH THE GOLGI COMPLEX AND HOW THESE MEMBRANES ARE COMPARTMENTALISED IN A FUNCTIONAL WAY. Finally, we hope that we can get to buy better the mechanisms that underlie the diseases related to the very functioning of the GOLGI COMPLEMENT._x000D_ to overwhelm the risks of this project, we use a new MULTIDISCIPLINAL BIOLOGY TOOLS TOOLS OF MOLECULAR AND CELL BIOLOGY, super-resolution nanoscopy and biophysic modelling. WE WILL FOCUS ON THREE MAIN OBJECTIVES: (1) TO ELUCIDATE THE CONTENTS OF THE INTRA-GOLGI TRANSPORT VESICLES; (2) STUDY THE LATERAL COMPARTMENTALISATION OF GOLGI MEMBRANES; And (3) DEVELOPING A QUANTITATIVE biophysical model of the intra-GOLGI TRAFIC based on our EXPERIMENTAL RESULTS._x000D_ THE NEWS OF THIS PROPOSES CONSISTE IN ASPECTS: PROVIDE CLEAR EXPERIMENTAL RESULTS ON THE CONTENT AND DIRECTIONALITY OF INTRA-GOLGI TRANSPORT VESICLES; THE USE OF SUPER-RESOLUTION NANOSCOPY TECHNIQUES TO STUDY THE LATERAL ORGANISATION OF GOLGI MEMBRANES; AND C) COMBINE ALL THIS INFORMATION TO PROPOSE AND CHARACTERISE IN A BIOPHYSICAL WAY A CONSENSUS MODEL FOR INTRA-GOLGI MEMBRANE TRAFFIC. THIS PROJECT IS FULLY ALIGNED WITH THE SOCIETAL CHALLENGE OF THE HORIZON 2020 PROGRAMME OF “HEALTH, DEMOGRAPHIC CHANGE AND WELL-BEING”, AS WE HOPE THAT OUR RESULTS WILL IMPROVE OUR UNDERSTANDING OF THE MECHANISMS RESPONSIBLE FOR DISEASES. In addition, one of the primary enabling technologies to be used is the super-resolution nanoscopy, included in the PHOTONIC, one of the “KEY Enabling TECHNOLOGIES” (KET) of the EC-H2020 programme._x000D_ in summary, we foresee that the results of this project will have a high impact on our vision of a fundamental part of the CELULAR BIOLOGY. IN PARTICULAR, WE HOPE THAT OUR RESULTS WILL BE HELPFUL IN DESIGNING NEW THERAPEUTIC OPTIONS AND TRACKING COMPOUNDS TO REVERSE THE PATHOLOGICAL EFFECTS OF VARIOUS DISEASES RELATED TO THE MALFUNCTION OF THE GOLGI COMPLEX. (English)
12 October 2021
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Castelldefels
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Identifiers
BFU2015-73288-JIN
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