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(Created claim: summary (P836): THIS PROJECT CONTAINS WHAT IS INTENDED TO BE THE BEGINNING OF MY CAREER AS A RESEARCHER RAMON Y CAJAL AT THE UNIVERSITY OF VIGO. DURING MY LAST FIVE YEARS OF RESEARCH I HAVE BEEN INTERESTED IN THE STUDY AND CHARACTERISATION OF THE EXTRACELLULAR PROTEINS OF PROBIOTIC BACTERIA AS MEDIATORS OF THE INTERCELLULAR COMMUNICATION BETWEEN THEM AND THE IMMUNE AND EPITHELIAL CELLS OF THE INTESTINAL MUCOSA. Recently we have uncovered a new FAMILY OF encrypt...) |
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THIS PROJECT CONTAINS WHAT IS INTENDED TO BE THE BEGINNING OF MY CAREER AS A RESEARCHER RAMON Y CAJAL AT THE UNIVERSITY OF VIGO. DURING MY LAST FIVE YEARS OF RESEARCH I HAVE BEEN INTERESTED IN THE STUDY AND CHARACTERISATION OF THE EXTRACELLULAR PROTEINS OF PROBIOTIC BACTERIA AS MEDIATORS OF THE INTERCELLULAR COMMUNICATION BETWEEN THEM AND THE IMMUNE AND EPITHELIAL CELLS OF THE INTESTINAL MUCOSA. Recently we have uncovered a new FAMILY OF encrypted immunomodulatory PEPTIDs DENTER OF EXTRACULAR PROTEINS SECRETATED BY PROBIOTICS, WITHOUT COURT POINTS FOR PRINCIPLE INTESTINAL PROTEASES, AND WE WILL BE FREEED OF THE SAME MODE OF THE BIOACTIVE PEPTIDS DERIVED OF LACTE PROTEIN PROTEINS._x000D_ in this PLANT RESEARCH PROJECT to delve deeper into the description and CHARACTERISATION of these encrypted PEPTIDs. WE WANT TO STUDY ITS ABUNDANCE IN THE EXOPROTEOMA OF THE HUMAN MICROBIOME (IN SILICO) USING ONLY THE AVAILABLE GENETIC SEQUENCES. SUBSEQUENTLY, THE DIFFERENT TYPES OF BIOACTIVITY OF THE DIFFERENT PEPTIDES ORIGINATED BY SIMULATED INTESTINAL DIGESTION WILL BE CHARACTERISED, FROM A THEORETICAL POINT OF VIEW, USING DIFFERENT COMPUTER TOOLS. FROM AMONG THE PEPTIDES FOUND, WE WILL SELECT THE 20 WITH THE GREATEST ANTI-INFLAMMATORY POTENTIAL. LATER WE WILL ESTABLISH ITS EFFECT ON DENDRITIC CELLS USING THE OMIC TECHNIQUES RNA-SEQ AND MBD OR CHIP-SEQ. THESE TECHNIQUES WILL GIVE US INFORMATION ON THE ACTION OF PEPTIDES FROM A TRANSCRIPTIONAL, EPIGENETIC AND REGULATORY POINT OF VIEW. I must stress that I will acquire experience in these technical graces to a project of mobility, granted at the expense of the European FP7, and in which I will study the INVESTMENT MECHANISMS OF THE RALSTONIA solanacearum DURANTE BACTERIA 2014._x000D_ The results of this research line will provide the base SCIENTIFICATION FOR ABOUT THE DEVELOPMENT OF NEW FUNCIONAL FOODS BASED IN BIOACTIVE PEPTIDS, DERIVED OF THE GENETIC SECUTIONS OF THE HUMAN MICROBIOMA. THESE FOODS WOULD BE AIMED BOTH AT THE PREVENTION OF AUTOIMMUNE AND INFLAMMATORY GASTROINTESTINAL DISEASES AND AT THE RELIEF OF THEIR SYMPTOMS IN SICK PATIENTS. This would have a direct repercussion by reducing the health costs of the treatment and increasing the quality of life of children._x000D_ this project supports it in full time by DRA ANALIA LOURENÇO, associated PROFESSIONAL OF INFORMATION DEPARTAMENT, AND PARTIAL TIME OF DR. FLORENTINO Riverola, PERTENECENT TO THE GROUP OF NEW GENERATION INFORMATION SYSTEMS. BOTH HAVE EXTENSIVE EXPERIENCE IN THE MANAGEMENT OF BIOACTIVE PEPTIDES DATABASES AND SYSTEMS BIOLOGY, AS WELL AS IN THE DEVELOPMENT OF BIOINFORMATICS TOOLS, AND DR. RIVEROLA IS THE DIRECTOR OF THE DEPARTMENT. I THINK THEY ARE PERFECT TO START THIS NEW LINE THAT INTEGRATES MOLECULAR BIOLOGY, CELLULAR BIOLOGY, OMICAS AND BIOINFORMATICA. CELL BIOLOGY EXPERIMENTS WILL BE PERFORMED USING IN VITRO DENDRITIC CELLS (CDS) IN THE CELL LINES LABORATORY OF IPLA-CSIC. FINALLY, I WOULD LIKE TO EMPHASISE THAT THIS PROJECT HAS THE SUPPORT OF RENOWNED RESEARCHERS IN IMMUNOLOGY (DR. STELLA KNIGHT, IMPERIAL COLLEGE LONDON), IN FOOD MICROBIOLOGY (DR. SIMON CARDING, INSTITUTE OF FOOD RESEARCH, NORWICH), IN FUNCTIONAL FEEDING (DR. HAIDONG TAN, GLYBOBIO LTD.) AND THE SPANISH ASSOCIATION OF CROHN’S DISEASE AND ULCERATIVE COLITIS. (English) | |||||||||||||||
| Property / summary: THIS PROJECT CONTAINS WHAT IS INTENDED TO BE THE BEGINNING OF MY CAREER AS A RESEARCHER RAMON Y CAJAL AT THE UNIVERSITY OF VIGO. DURING MY LAST FIVE YEARS OF RESEARCH I HAVE BEEN INTERESTED IN THE STUDY AND CHARACTERISATION OF THE EXTRACELLULAR PROTEINS OF PROBIOTIC BACTERIA AS MEDIATORS OF THE INTERCELLULAR COMMUNICATION BETWEEN THEM AND THE IMMUNE AND EPITHELIAL CELLS OF THE INTESTINAL MUCOSA. Recently we have uncovered a new FAMILY OF encrypted immunomodulatory PEPTIDs DENTER OF EXTRACULAR PROTEINS SECRETATED BY PROBIOTICS, WITHOUT COURT POINTS FOR PRINCIPLE INTESTINAL PROTEASES, AND WE WILL BE FREEED OF THE SAME MODE OF THE BIOACTIVE PEPTIDS DERIVED OF LACTE PROTEIN PROTEINS._x000D_ in this PLANT RESEARCH PROJECT to delve deeper into the description and CHARACTERISATION of these encrypted PEPTIDs. WE WANT TO STUDY ITS ABUNDANCE IN THE EXOPROTEOMA OF THE HUMAN MICROBIOME (IN SILICO) USING ONLY THE AVAILABLE GENETIC SEQUENCES. SUBSEQUENTLY, THE DIFFERENT TYPES OF BIOACTIVITY OF THE DIFFERENT PEPTIDES ORIGINATED BY SIMULATED INTESTINAL DIGESTION WILL BE CHARACTERISED, FROM A THEORETICAL POINT OF VIEW, USING DIFFERENT COMPUTER TOOLS. FROM AMONG THE PEPTIDES FOUND, WE WILL SELECT THE 20 WITH THE GREATEST ANTI-INFLAMMATORY POTENTIAL. LATER WE WILL ESTABLISH ITS EFFECT ON DENDRITIC CELLS USING THE OMIC TECHNIQUES RNA-SEQ AND MBD OR CHIP-SEQ. THESE TECHNIQUES WILL GIVE US INFORMATION ON THE ACTION OF PEPTIDES FROM A TRANSCRIPTIONAL, EPIGENETIC AND REGULATORY POINT OF VIEW. I must stress that I will acquire experience in these technical graces to a project of mobility, granted at the expense of the European FP7, and in which I will study the INVESTMENT MECHANISMS OF THE RALSTONIA solanacearum DURANTE BACTERIA 2014._x000D_ The results of this research line will provide the base SCIENTIFICATION FOR ABOUT THE DEVELOPMENT OF NEW FUNCIONAL FOODS BASED IN BIOACTIVE PEPTIDS, DERIVED OF THE GENETIC SECUTIONS OF THE HUMAN MICROBIOMA. THESE FOODS WOULD BE AIMED BOTH AT THE PREVENTION OF AUTOIMMUNE AND INFLAMMATORY GASTROINTESTINAL DISEASES AND AT THE RELIEF OF THEIR SYMPTOMS IN SICK PATIENTS. This would have a direct repercussion by reducing the health costs of the treatment and increasing the quality of life of children._x000D_ this project supports it in full time by DRA ANALIA LOURENÇO, associated PROFESSIONAL OF INFORMATION DEPARTAMENT, AND PARTIAL TIME OF DR. FLORENTINO Riverola, PERTENECENT TO THE GROUP OF NEW GENERATION INFORMATION SYSTEMS. BOTH HAVE EXTENSIVE EXPERIENCE IN THE MANAGEMENT OF BIOACTIVE PEPTIDES DATABASES AND SYSTEMS BIOLOGY, AS WELL AS IN THE DEVELOPMENT OF BIOINFORMATICS TOOLS, AND DR. RIVEROLA IS THE DIRECTOR OF THE DEPARTMENT. I THINK THEY ARE PERFECT TO START THIS NEW LINE THAT INTEGRATES MOLECULAR BIOLOGY, CELLULAR BIOLOGY, OMICAS AND BIOINFORMATICA. CELL BIOLOGY EXPERIMENTS WILL BE PERFORMED USING IN VITRO DENDRITIC CELLS (CDS) IN THE CELL LINES LABORATORY OF IPLA-CSIC. FINALLY, I WOULD LIKE TO EMPHASISE THAT THIS PROJECT HAS THE SUPPORT OF RENOWNED RESEARCHERS IN IMMUNOLOGY (DR. STELLA KNIGHT, IMPERIAL COLLEGE LONDON), IN FOOD MICROBIOLOGY (DR. SIMON CARDING, INSTITUTE OF FOOD RESEARCH, NORWICH), IN FUNCTIONAL FEEDING (DR. HAIDONG TAN, GLYBOBIO LTD.) AND THE SPANISH ASSOCIATION OF CROHN’S DISEASE AND ULCERATIVE COLITIS. (English) / rank | |||||||||||||||
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| Property / summary: THIS PROJECT CONTAINS WHAT IS INTENDED TO BE THE BEGINNING OF MY CAREER AS A RESEARCHER RAMON Y CAJAL AT THE UNIVERSITY OF VIGO. DURING MY LAST FIVE YEARS OF RESEARCH I HAVE BEEN INTERESTED IN THE STUDY AND CHARACTERISATION OF THE EXTRACELLULAR PROTEINS OF PROBIOTIC BACTERIA AS MEDIATORS OF THE INTERCELLULAR COMMUNICATION BETWEEN THEM AND THE IMMUNE AND EPITHELIAL CELLS OF THE INTESTINAL MUCOSA. Recently we have uncovered a new FAMILY OF encrypted immunomodulatory PEPTIDs DENTER OF EXTRACULAR PROTEINS SECRETATED BY PROBIOTICS, WITHOUT COURT POINTS FOR PRINCIPLE INTESTINAL PROTEASES, AND WE WILL BE FREEED OF THE SAME MODE OF THE BIOACTIVE PEPTIDS DERIVED OF LACTE PROTEIN PROTEINS._x000D_ in this PLANT RESEARCH PROJECT to delve deeper into the description and CHARACTERISATION of these encrypted PEPTIDs. WE WANT TO STUDY ITS ABUNDANCE IN THE EXOPROTEOMA OF THE HUMAN MICROBIOME (IN SILICO) USING ONLY THE AVAILABLE GENETIC SEQUENCES. SUBSEQUENTLY, THE DIFFERENT TYPES OF BIOACTIVITY OF THE DIFFERENT PEPTIDES ORIGINATED BY SIMULATED INTESTINAL DIGESTION WILL BE CHARACTERISED, FROM A THEORETICAL POINT OF VIEW, USING DIFFERENT COMPUTER TOOLS. FROM AMONG THE PEPTIDES FOUND, WE WILL SELECT THE 20 WITH THE GREATEST ANTI-INFLAMMATORY POTENTIAL. LATER WE WILL ESTABLISH ITS EFFECT ON DENDRITIC CELLS USING THE OMIC TECHNIQUES RNA-SEQ AND MBD OR CHIP-SEQ. THESE TECHNIQUES WILL GIVE US INFORMATION ON THE ACTION OF PEPTIDES FROM A TRANSCRIPTIONAL, EPIGENETIC AND REGULATORY POINT OF VIEW. I must stress that I will acquire experience in these technical graces to a project of mobility, granted at the expense of the European FP7, and in which I will study the INVESTMENT MECHANISMS OF THE RALSTONIA solanacearum DURANTE BACTERIA 2014._x000D_ The results of this research line will provide the base SCIENTIFICATION FOR ABOUT THE DEVELOPMENT OF NEW FUNCIONAL FOODS BASED IN BIOACTIVE PEPTIDS, DERIVED OF THE GENETIC SECUTIONS OF THE HUMAN MICROBIOMA. THESE FOODS WOULD BE AIMED BOTH AT THE PREVENTION OF AUTOIMMUNE AND INFLAMMATORY GASTROINTESTINAL DISEASES AND AT THE RELIEF OF THEIR SYMPTOMS IN SICK PATIENTS. This would have a direct repercussion by reducing the health costs of the treatment and increasing the quality of life of children._x000D_ this project supports it in full time by DRA ANALIA LOURENÇO, associated PROFESSIONAL OF INFORMATION DEPARTAMENT, AND PARTIAL TIME OF DR. FLORENTINO Riverola, PERTENECENT TO THE GROUP OF NEW GENERATION INFORMATION SYSTEMS. BOTH HAVE EXTENSIVE EXPERIENCE IN THE MANAGEMENT OF BIOACTIVE PEPTIDES DATABASES AND SYSTEMS BIOLOGY, AS WELL AS IN THE DEVELOPMENT OF BIOINFORMATICS TOOLS, AND DR. RIVEROLA IS THE DIRECTOR OF THE DEPARTMENT. I THINK THEY ARE PERFECT TO START THIS NEW LINE THAT INTEGRATES MOLECULAR BIOLOGY, CELLULAR BIOLOGY, OMICAS AND BIOINFORMATICA. CELL BIOLOGY EXPERIMENTS WILL BE PERFORMED USING IN VITRO DENDRITIC CELLS (CDS) IN THE CELL LINES LABORATORY OF IPLA-CSIC. FINALLY, I WOULD LIKE TO EMPHASISE THAT THIS PROJECT HAS THE SUPPORT OF RENOWNED RESEARCHERS IN IMMUNOLOGY (DR. STELLA KNIGHT, IMPERIAL COLLEGE LONDON), IN FOOD MICROBIOLOGY (DR. SIMON CARDING, INSTITUTE OF FOOD RESEARCH, NORWICH), IN FUNCTIONAL FEEDING (DR. HAIDONG TAN, GLYBOBIO LTD.) AND THE SPANISH ASSOCIATION OF CROHN’S DISEASE AND ULCERATIVE COLITIS. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 14:44, 12 October 2021
Project Q3149933 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3149933 in Spain |
Statements
116,160.0 Euro
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145,200.0 Euro
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80.0 percent
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1 January 2014
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31 December 2017
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AGENCIA CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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43°28'52.79"N, 5°26'0.46"W
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33076
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ESTE PROYECTO CONTIENE LO QUE PRETENDE SER EL COMIENZO DE MI ANDADURA COMO INVESTIGADOR RAMON Y CAJAL EN LA UNIVERSIDAD DE VIGO. DURANTE MIS ULTIMOS CINCO AÑOS DE INVESTIGACION ME HE INTERESADO POR EL ESTUDIO Y CARACTERIZACION DE LAS PROTEINAS EXTRACELULARES DE BACTERIAS PROBIOTICAS COMO MEDIADORES DE LA COMUNICACION INTERCELULAR ENTRE ELLAS Y LAS CELULAS INMUNES Y EPITELIALES DE LA MUCOSA INTESTINAL. RECIENTEMENTE HEMOS DESCUBIERTO UNA NUEVA FAMILIA DE PEPTIDOS INMUNOMODULADORES ENCRIPTADOS DENTRO DE PROTEINAS EXTRACELULARES SECRETADAS POR PROBIOTICOS, SIN PUNTOS DE CORTE PARA LAS PRINCIPALES PROTEASAS INTESTINALES, Y QUE SERIAN LIBERADOS DEL MISMO MODO QUE LOS PEPTIDOS BIOACTIVOS DERIVADOS DE LAS PROTEINAS LACTEAS._x000D_ EN ESTE PROYECTO DE INVESTIGACION PLANTEO AHONDAR EN LA DESCRIPCION Y CARACTERIZACION DE ESTOS PEPTIDOS ENCRIPTADOS. QUEREMOS ESTUDIAR SU ABUNDANCIA EN EL EXOPROTEOMA DEL MICROBIOMA HUMANO (IN SILICO) UTILIZANDO SOLO LAS SECUENCIAS GENETICAS DISPONIBLES. POSTERIORMENTE SE CARACTERIZARAN LOS DISTINTOS TIPOS DE BIOACTIVIDAD DE LOS DISTINTOS PEPTIDOS ORIGINADOS POR DIGESTION INTESTINAL SIMULADA, DESDE UN PUNTO DE VISTA TEORICO, UTILIZANDO DISTINTAS HERRAMIENTAS INFORMATICAS. DE ENTRE LOS PEPTIDOS ENCONTRADOS, SELECCIONAREMOS LOS 20 QUE PRESENTEN UN MAYOR POTENCIAL ANTIINFLAMATORIO. POSTERIORMENTE ESTABLECEREMOS SU EFECTO SOBRE CELULAS DENDRITICAS MEDIANTE LAS TECNICAS OMICAS RNA-SEQ Y MBD O CHIP-SEQ. ESTAS TECNICAS NOS DARAN INFORMACION DE LA ACCION DE LOS PEPTIDOS DESDE UN PUNTO DE VISTA TRANSCRIPCIONAL, EPIGENETICO Y REGULADOR. HE DE RESALTAR QUE ADQUIRIRE EXPERIENCIA EN ESTAS TECNICAS GRACIAS A UN PROYECTO DE MOVILIDAD, CONCEDIDO A CARGO DEL FP7 EUROPEO, Y EN EL QUE ESTUDIARE LOS MECANISMOS DE INVASION DE LA BACTERIA RALSTONIA SOLANACEARUM DURANTE 2014._x000D_ LOS RESULTADOS DE ESTA LINEA DE INVESTIGACION PROPORCIONARAN LA BASE CIENTIFICA PARA ABORDAR EL DESARROLLO DE NUEVOS ALIMENTOS FUNCIONALES BASADOS EN PEPTIDOS BIOACTIVOS, DERIVADOS DE LAS SECUENCIAS GENETICAS DEL MICROBIOMA HUMANO. ESTOS ALIMENTOS ESTARIAN DIRIGIDOS TANTO A LA PREVENCION DE ENFERMEDADES GASTROINTESTINALES DE TIPO AUTOINMUNE E INFLAMATORIO COMO AL ALIVIO DE SUS SINTOMAS EN PACIENTES ENFERMOS. ESTO TENDRIA UNA REPERCUSION DIRECTA DISMINUYENDO LOS COSTES SANITARIOS DE LOS TRATAMIENTOS Y AUMENTANDO LA CALIDAD DE VIDA DE LOS ENFERMOS._x000D_ ESTE PROYECTO LO APOYA A TIEMPO COMPLETO LA DRA ANALIA LOURENÇO, PROFESORA ASOCIADA DEL DEPARTAMENTO DE INFORMATICA, Y A TIEMPO PARCIAL DEL DR. FLORENTINO RIVEROLA, PERTENECIENTES AL GRUPO DE SISTEMAS INFORMATICOS DE NUEVA GENERACION. AMBOS TIENEN AMPLIA EXPERIENCIA EN EL MANEJO DE BASES DE DATOS DE PEPTIDOS BIOACTIVOS Y DE BIOLOGIA DE SISTEMAS, ASI COMO EN EL DESARROLLO DE HERRAMIENTAS BIOINFORMATICAS, Y ADEMAS EL DR. RIVEROLA ES EL DIRECTOR DEL DEPARTAMENTO. CONSIDERO QUE SON PERFECTOS PARA COMENZAR ESTA NUEVA LINEA QUE INTEGRA BIOLOGIA MOLECULAR, BIOLOGIA CELULAR, OMICAS Y BIOINFORMATICA. LOS EXPERIMENTOS DE BIOLOGIA CELULAR SE REALIZARAN UTILIZANDO CELULAS DENDRITICAS (CDS) IN VITRO, EN EL LABORATORIO DE LINEAS CELULARES DEL IPLA-CSIC. FINALMENTE QUISIERA DESTACAR QUE ESTE PROYECTO CUENTA CON EL APOYO DE INVESTIGADORES DE RECONOCIDO PRESTIGIO EN INMUNOLOGIA (DRA. STELLA KNIGHT, IMPERIAL COLLEGE LONDON), EN MICROBIOLOGIA DE ALIMENTOS (DR. SIMON CARDING, INSTITUTE OF FOOD RESEARCH, NORWICH), EN ALIMENTACION FUNCIONAL (DR. HAIDONG TAN, GLYBOBIO LTD.) Y DE LA ASOCIACION ESPAÑOLA DE ENFERMEDAD DE CROHN Y COLITIS ULCEROSA. (Spanish)
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THIS PROJECT CONTAINS WHAT IS INTENDED TO BE THE BEGINNING OF MY CAREER AS A RESEARCHER RAMON Y CAJAL AT THE UNIVERSITY OF VIGO. DURING MY LAST FIVE YEARS OF RESEARCH I HAVE BEEN INTERESTED IN THE STUDY AND CHARACTERISATION OF THE EXTRACELLULAR PROTEINS OF PROBIOTIC BACTERIA AS MEDIATORS OF THE INTERCELLULAR COMMUNICATION BETWEEN THEM AND THE IMMUNE AND EPITHELIAL CELLS OF THE INTESTINAL MUCOSA. Recently we have uncovered a new FAMILY OF encrypted immunomodulatory PEPTIDs DENTER OF EXTRACULAR PROTEINS SECRETATED BY PROBIOTICS, WITHOUT COURT POINTS FOR PRINCIPLE INTESTINAL PROTEASES, AND WE WILL BE FREEED OF THE SAME MODE OF THE BIOACTIVE PEPTIDS DERIVED OF LACTE PROTEIN PROTEINS._x000D_ in this PLANT RESEARCH PROJECT to delve deeper into the description and CHARACTERISATION of these encrypted PEPTIDs. WE WANT TO STUDY ITS ABUNDANCE IN THE EXOPROTEOMA OF THE HUMAN MICROBIOME (IN SILICO) USING ONLY THE AVAILABLE GENETIC SEQUENCES. SUBSEQUENTLY, THE DIFFERENT TYPES OF BIOACTIVITY OF THE DIFFERENT PEPTIDES ORIGINATED BY SIMULATED INTESTINAL DIGESTION WILL BE CHARACTERISED, FROM A THEORETICAL POINT OF VIEW, USING DIFFERENT COMPUTER TOOLS. FROM AMONG THE PEPTIDES FOUND, WE WILL SELECT THE 20 WITH THE GREATEST ANTI-INFLAMMATORY POTENTIAL. LATER WE WILL ESTABLISH ITS EFFECT ON DENDRITIC CELLS USING THE OMIC TECHNIQUES RNA-SEQ AND MBD OR CHIP-SEQ. THESE TECHNIQUES WILL GIVE US INFORMATION ON THE ACTION OF PEPTIDES FROM A TRANSCRIPTIONAL, EPIGENETIC AND REGULATORY POINT OF VIEW. I must stress that I will acquire experience in these technical graces to a project of mobility, granted at the expense of the European FP7, and in which I will study the INVESTMENT MECHANISMS OF THE RALSTONIA solanacearum DURANTE BACTERIA 2014._x000D_ The results of this research line will provide the base SCIENTIFICATION FOR ABOUT THE DEVELOPMENT OF NEW FUNCIONAL FOODS BASED IN BIOACTIVE PEPTIDS, DERIVED OF THE GENETIC SECUTIONS OF THE HUMAN MICROBIOMA. THESE FOODS WOULD BE AIMED BOTH AT THE PREVENTION OF AUTOIMMUNE AND INFLAMMATORY GASTROINTESTINAL DISEASES AND AT THE RELIEF OF THEIR SYMPTOMS IN SICK PATIENTS. This would have a direct repercussion by reducing the health costs of the treatment and increasing the quality of life of children._x000D_ this project supports it in full time by DRA ANALIA LOURENÇO, associated PROFESSIONAL OF INFORMATION DEPARTAMENT, AND PARTIAL TIME OF DR. FLORENTINO Riverola, PERTENECENT TO THE GROUP OF NEW GENERATION INFORMATION SYSTEMS. BOTH HAVE EXTENSIVE EXPERIENCE IN THE MANAGEMENT OF BIOACTIVE PEPTIDES DATABASES AND SYSTEMS BIOLOGY, AS WELL AS IN THE DEVELOPMENT OF BIOINFORMATICS TOOLS, AND DR. RIVEROLA IS THE DIRECTOR OF THE DEPARTMENT. I THINK THEY ARE PERFECT TO START THIS NEW LINE THAT INTEGRATES MOLECULAR BIOLOGY, CELLULAR BIOLOGY, OMICAS AND BIOINFORMATICA. CELL BIOLOGY EXPERIMENTS WILL BE PERFORMED USING IN VITRO DENDRITIC CELLS (CDS) IN THE CELL LINES LABORATORY OF IPLA-CSIC. FINALLY, I WOULD LIKE TO EMPHASISE THAT THIS PROJECT HAS THE SUPPORT OF RENOWNED RESEARCHERS IN IMMUNOLOGY (DR. STELLA KNIGHT, IMPERIAL COLLEGE LONDON), IN FOOD MICROBIOLOGY (DR. SIMON CARDING, INSTITUTE OF FOOD RESEARCH, NORWICH), IN FUNCTIONAL FEEDING (DR. HAIDONG TAN, GLYBOBIO LTD.) AND THE SPANISH ASSOCIATION OF CROHN’S DISEASE AND ULCERATIVE COLITIS. (English)
12 October 2021
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Villaviciosa
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Identifiers
AGL2013-44039-R
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