Development of bioactive and biodegradable platforms for endoscopic treatment of colon and rectal cancer (Q3142777): Difference between revisions
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(Created claim: summary (P836): Objectives: Development of bioactive platforms for endoscopic treatment of colon and rectal cancer (CCR), which allow the release of drugs, with mechanical and bioactive activity. Methodology: 1)-Prevention of recurrence of after endoscopic resection of CRC, by applying bioactive hydrogels in an experimental model of RCC by azoxymethane in rats. 2)-Bioactive endoscopic treatment of malignant colon stenosis by: a) Develop biodegradable plat...) |
(Changed label, description and/or aliases in en: translated_label) |
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| label / en | label / en | ||
Development of bioactive and biodegradable platforms for endoscopic treatment of colon and rectal cancer | |||
Revision as of 13:49, 12 October 2021
Project Q3142777 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Development of bioactive and biodegradable platforms for endoscopic treatment of colon and rectal cancer |
Project Q3142777 in Spain |
Statements
38,250.0 Euro
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76,500.0 Euro
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50.0 percent
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1 January 2017
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31 March 2020
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FUNDACION INSTITUTO DE INVESTIGACION EN CIENCIAS DE LA SALUD GERMANS TRIAS I PUJOL
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41°26'57.66"N, 2°14'53.70"E
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08015
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Objetivos: Desarrollo de plataformas bioactivas para el tratamiento endoscópico del cáncer de colon y recto (CCR), que permitan la liberación de fármacos, con actividad mecánica y bioactiva. Metodología: 1)-Prevención de la recurrencia del tras la resección endoscópica del CCR, mediante la aplicación de hidrogeles bioactivos en un modelo experimental de CCR por azoximetano en ratas. 2)-Tratamiento endoscópico bioactivo de las estenosis malignas del colon, mediante: a)-Desarrollar plataformas biodegradables mediante reticulación irreversible generadas por impresión en 3D, mediante la combinación de diferentes biomateriales. b)-Optimización del diseño de las estructuras Bio3D: estructura cilíndrica para el tratamiento de las estenosis, o laminar para cubrir defectos mucosos extensos. c)-Incorporar los tratamientos específicos del CCR y comprobar la eficacia terapéutica de las plataformas Bio3D en un modelo experimental de cáncer de colon por azoximetano 3) Utilizar las plataformas Bio3D como matriz sobre la que asentar mediante cultivo células del huésped, para acelerar la reepitelización fisiológica tras la resección endoscópica. (Spanish)
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Objectives: Development of bioactive platforms for endoscopic treatment of colon and rectal cancer (CCR), which allow the release of drugs, with mechanical and bioactive activity. Methodology: 1)-Prevention of recurrence of after endoscopic resection of CRC, by applying bioactive hydrogels in an experimental model of RCC by azoxymethane in rats. 2)-Bioactive endoscopic treatment of malignant colon stenosis by: a) Develop biodegradable platforms through irreversible crosslinking generated by 3D printing, by combining different biomaterials. B)-Optimisation of the design of Bio3D structures: cylindrical structure for the treatment of stenosis, or laminar to cover extensive mucous defects. C)-Incorporate specific RCC treatments and check the therapeutic efficacy of Bio3D platforms in an experimental model of azoxymethane colon cancer 3) Use Bio3D platforms as a matrix on which to settle host cells by culture, to accelerate physiological reepithelisation after endoscopic resection. (English)
12 October 2021
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Badalona
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Identifiers
PI16_01928
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