STUDY OF ENANTIOSELECTIVE BIODEGRADATION OF EMERGING CHIRAL CONTAMINANTS. HEALTH AND ENVIRONMENTAL IMPLICATIONS AND RISKS. (Q3136894): Difference between revisions
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(Created claim: summary (P836): THIS PROJECT RESPONDS TO THE NEED TO ASSESS THE HEALTH AND ENVIRONMENTAL RISKS OF EMERGING POLLUTANTS, ESPECIALLY CHIRAL CONTAMINANTS ENANTIOMERS, OF WHICH LITTLE OR NO INFORMATION IS AVAILABLE. IN PARTICULAR, THE PROJECT WILL EVALUATE THE DEGREE OF ENANTIOSELECTIVE BIODEGRADATION SUFFERED BY CHIRAL CONTAMINANTS IN WASTE WATER AFTER TREATMENT TREATMENT (WWTP PLANTS) THAT USE ACTIVATED SLUDGE AS BIOREACTOR. SINCE ENVIRONMENTAL RESEARCH HAS UNDERE...) |
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STUDY OF ENANTIOSELECTIVE BIODEGRADATION OF EMERGING CHIRAL CONTAMINANTS. HEALTH AND ENVIRONMENTAL IMPLICATIONS AND RISKS. | |||
Revision as of 13:40, 12 October 2021
Project Q3136894 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | STUDY OF ENANTIOSELECTIVE BIODEGRADATION OF EMERGING CHIRAL CONTAMINANTS. HEALTH AND ENVIRONMENTAL IMPLICATIONS AND RISKS. |
Project Q3136894 in Spain |
Statements
36,300.0 Euro
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72,600.0 Euro
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50.0 percent
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1 January 2016
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31 December 2019
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UNIVERSIDAD DE VALENCIA
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39°30'32.62"N, 0°24'39.10"W
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46078
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ESTE PROYECTO RESPONDE A LA NECESIDAD DE EVALUAR LOS RIESGOS PARA LA SALUD Y EL MEDIO AMBIENTE DE LOS CONTAMINANTES EMERGENTES, ESPECIALMENTE, LOS ENANTIOMEROS DE CONTAMINANTES QUIRALES, DE LOS QUE SE DISPONE POCA O NINGUNA INFORMACION. EN CONCRETO, EN EL PROYECTO SE EVALUARA EL GRADO DE BIODEGRADACION ENANTIOSELECTIVA QUE SUFREN LOS CONTAMINANTES QUIRALES EN AGUAS RESIDUALES TRAS SU TRATAMIENTO DE DEPURACION (PLANTAS EDAR) QUE EMPLEEN LODOS ACTIVADOS COMO BIORREACTOR. PUESTO QUE LA INVESTIGACION MEDIOAMBIENTAL HA INFRAESTIMADO LA (ECO)TOXICIDAD DIFERENCIAL DE LOS ENANTIOMEROS Y APENAS EXISTE INFORMACION SOBRE DEGRADACION ENANTIOSELECTIVA, SE PUEDE AFIRMAR QUE EN LA ACTUALIDAD EXISTE UNA EVALUACION INCORRECTA DEL RIESGO MEDIOAMBIENTAL Y SANITARIO RELACIONADO LAS AGUAS RESIDUALES TRATADAS. LOS ESTUDIOS SE CENTRARAN FUNDAMENTALMENTE EN FARMACOS QUIRALES DE ELEVADO CONSUMO HUMANO (ANTIINFLAMATORIOS, ANALGESICOS, ANTIDEPRESIVOS, SEDANTES, ANTIEPILEPTICOS), FARMACOS CARDIOVASCULARES (EJ. -BLOQUEANTES), CITOSTATICOS (MUY TOXICOS Y CON APARENTE BAJA DEGRADACION) Y PLAGUICIDAS QUIRALES INCLUIDOS EN LAS LISTAS PRIORITARIAS._x000D_ LOS OBJETIVOS A DESARROLLAR INCLUIRAN: (1) ESTUDIO DE LA BIODEGRADACION (NORMATIVA OCDE) DE CONTAMINANTES CON LODOS ACTIVOS DE DEPURADORA Y ELECTROFORESIS CAPILAR PARA MONITORIZAR LA DISMINUCION DE LA CONCENTRACION DEL CONTAMINANTE CON EL TIEMPO. SE SIMULARAN EN EL_x000D_ LABORATORIO LOS FENOMENOS DE PLANTA EDAR. (2) DESARROLLO DE METODOS (ELECTROFORETICOS Y CROMATOGRAFICOS) ENANTIOSELECTIVOS PARA LA SEPARACION DE LOS CONTAMINANTES QUIRALES. (3) ESTUDIOS DE BIODEGRADACION ENANTIOSELECTIVA DE CONTAMINANTES CON LODOS ACTIVOS DE DEPURADORA MEDIANTE ENSAYOS DE BIODEGRADABILIDAD Y ELECTROFORESIS CAPILAR (EKC). (4) ESCALABILIDAD DE LOS ESTUDIOS Y TRANSFERIBILIDAD DE LOS PERFILES DE DEGRADACION, PARA TRASLADAR RESULTADOS DESDE LA ESCALA DE LABORATORIO, HASTA LOS NIVELES DE CONCENTRACION REALES EN AGUAS RESIDUALES, COMBINANDO TECNICAS DE PRECONCENTRACION CON TECNICAS ANALITICAS MAS SENSIBLES, COMO LA CROMATOGRAFIA LIQUIDA CON DETECCION POR ESPECTROMETRIA DE MASAS (MS) Y ESPECTROMETRIA DE MASAS EN TANDEM (MS/MS). (5) DESARROLLO DE MODELOS PREDICTIVOS DE BIODEGRADACION GLOBAL Y ENANTIOSELECTIVA, EMPLEANDO RESULTADOS DE UN NUMERO SUFICIENTE DE CONTAMINANTES, Y DEFINIENDO EL PERFIL DE BIODEGRADACION GLOBAL Y ENANTIOSELECTIVO DEL AGENTE BIOLOGICO ESTUDIADO Y CREANDO MODELOS PREDICTIVOS DE LA CAPACIDAD DE BIODEGRADACION GLOBAL Y ENANTIOSELECTIVA PARA NUEVOS CONTAMINANTES. ALGO NUNCA ANTES ESTUDIADO._x000D_ LOS RESULTADOS OBTENIDOS (PORCENTAJE Y CONSTANTE DE VELOCIDAD DE BIODEGRADACION, TIEMPO DE VIDA MEDIA, FRACCION ENANTIOMERICA) SERAN FRUTO DE LA SINERGIA ENTRE LA EXPERIENCIA DE NUESTRO GRUPO DE INVESTIGACION (GAMM-CYMAR) EN EL DESARROLLO DE METODOLOGIAS ANALITICAS ENANTIOSELECTIVAS Y ESTUDIOS DE ENANTIODIFERENCIACION, CON LA DEL LABORATORIO GAMASER S.L. (DEL GRUPO AGUAS DE VALENCIA, S.A.) SOBRE LAS DISTINTAS ETAPAS DEL CICLO INTEGRAL DEL AGUA Y DE DESARROLLO DE LA NORMA I+D+I (ISO 166002:2002). LAS CONCLUSIONES OBTENIDAS PUEDEN RESULTAR TAMBIEN DE INTERES EN LOS ENTORNOS HOMOLOGADOS DE GAMASER S.L. QUE INCLUYEN VARIAS COMUNIDADES AUTONOMAS Y SUS TAREAS DE INSPECCION DE AMBITO NACIONAL. LOS RESULTADOS SERVIRAN PARA SOLICITAR UNA AYUDA EUROPEA (WATER JPI) E INTERNACIONALIZAR LOS ESTUDIOS, DADO EL ALTO GRADO DE SOLAPAMIENTO CON SUS RETOS (Spanish)
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THIS PROJECT RESPONDS TO THE NEED TO ASSESS THE HEALTH AND ENVIRONMENTAL RISKS OF EMERGING POLLUTANTS, ESPECIALLY CHIRAL CONTAMINANTS ENANTIOMERS, OF WHICH LITTLE OR NO INFORMATION IS AVAILABLE. IN PARTICULAR, THE PROJECT WILL EVALUATE THE DEGREE OF ENANTIOSELECTIVE BIODEGRADATION SUFFERED BY CHIRAL CONTAMINANTS IN WASTE WATER AFTER TREATMENT TREATMENT (WWTP PLANTS) THAT USE ACTIVATED SLUDGE AS BIOREACTOR. SINCE ENVIRONMENTAL RESEARCH HAS UNDERESTIMATED THE DIFFERENTIAL (ECO)TOXICITY OF ENANTIOMERS AND THERE IS LITTLE INFORMATION ON ENANTIOS-SELECTIVE DEGRADATION, IT CAN BE SAID THAT THERE IS CURRENTLY AN INCORRECT ASSESSMENT OF THE RELATED ENVIRONMENTAL AND HEALTH RISK OF TREATED WASTEWATER. The STUDIES will focus FUNDAMENTLY on chiral pharmacies of HUMAN CONSUMPTION (ANTIINFLAMATORIES, analgesics, ANTIDEPRESIVES, SEDANTS, antiepileptics), CARDIOVASCULAR FARMACOS (e.g. -BLOQUEANTS), CYTOSTATICS (very TOXICOS AND WITH LOW DEGRADATION) and chiral PLAGUICIDAS included IN PRIORITARY LISTS._x000D_ OBJECTIVES TO DEVELOP shall include: (1) STUDY OF BIODEGRADATION (OECD REGULATION) OF CONTAMINANTS WITH ACTIVE SEWAGE SLUDGE AND CAPILLARY ELECTROPHORESIS TO MONITOR THE DECREASE IN THE CONCENTRATION OF THE POLLUTANT OVER TIME. Be simulated IN THE_x000D_ LABORATORY THE WAR PLAN PENOMENS. (2) DEVELOPMENT OF METHODS (ELECTROFORETIC AND CROMATOGRAPHIC) ENANTIOSELECTIVES FOR THE SEPARATION OF CHIRAL CONTAMINANTS. (3) STUDIES OF ENANTIOS-SELECTIVE BIODEGRADATION OF CONTAMINANTS WITH ACTIVE SEWAGE SLUDGE THROUGH BIODEGRADABILITY AND CAPILLARY ELECTROPHORESIS (EKC) TESTS. (4) SCALABILITY OF STUDIES AND TRANSFERABILITY OF DEGRADATION PROFILES, TO TRANSFER RESULTS FROM THE LABORATORY SCALE TO ACTUAL CONCENTRATION LEVELS IN WASTEWATER, COMBINING PRECONCENTRATION TECHNIQUES WITH MORE SENSITIVE ANALYTIC TECHNIQUES, SUCH AS LIQUID CHROMATOGRAPHING WITH MASS SPECTROMETRY (MS) DETECTION AND MASS SPECTROMETRY IN TANDEM (MS/MS). (5) DEVELOPMENT OF PREDICTIVE MODELS OF GLOBAL AND ENANTI-OSELECTIVE BIODEGRADATION, USING RESULTS FROM A SUFFICIENT NUMBER OF POLLUTANTS, AND DEFINING THE OVERALL AND ENANTIOSELECTIVO BIODEGRADATION PROFILE OF THE BIOLOGICAL AGENT STUDIED AND CREATING PREDICTIVE MODELS OF THE CAPACITY OF GLOBAL AND ENANTIOSELECTIVE BIODEGRADATION FOR NEW POLLUTANTS. Something NEVER BEFORE STUDED._x000D_ OBTENTED RESULTS (PORCENTACE AND CONSTANT OF VELOCITY OF Biodegradation, MEDIA LIFE TIME, ENANTIOMERICA FRACTION) BEING FRUT OF SINERGY BETWEEN THE EXPERIENCE OF OUR RESEARCH GROUP (GAMM-CYMAR) IN DEVELOPMENT of enanti-selective analytic methods AND ENANTIODIFERENTIAL STUDIES, WITH THE LABORATORIO GAMASER S.L. (DEL GRUPO AGUAS DE VALENCIA, S.A.) ON THE DYSTINT ETAPAS OF THE INTEGRAL CYSTEM OF WATER AND DEVELOPMENT OF THE NORMA R & D+I (ISO 166002:2002). THE CONCLUSIONS OBTAINED MAY ALSO BE OF INTEREST IN THE APPROVED ENVIRONMENTS OF GAMASER S.L. WHICH INCLUDE SEVERAL AUTONOMOUS COMMUNITIES AND THEIR TASKS OF NATIONAL INSPECTION. THE RESULTS WILL BE USED TO APPLY FOR EUROPEAN ASSISTANCE (WATER JPI) AND TO INTERNATIONALISE THE STUDIES, GIVEN THE HIGH DEGREE OF OVERLAP WITH ITS CHALLENGES (English)
12 October 2021
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Burjassot
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Identifiers
CTQ2015-70904-R
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