Study of hippocampus subregions in first episodes of psychosis: Longitudinal analysis at 10 years. (Q3136786): Difference between revisions
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(Created claim: summary (P836): There is a broad interest in the characterisation of the hippocampus in the field of schizophrenia since it is a region that, according to several lines of evidence, can play a major role in clinical, functional and cognitive abnormalities found in this disease. The objective of the project presented is to use an innovative method of segmentation of hippocampal subregions to examine long-term longitudinal change and its association with clinica...) |
(Changed label, description and/or aliases in en: translated_label) |
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Study of hippocampus subregions in first episodes of psychosis: Longitudinal analysis at 10 years. | |||
Revision as of 13:39, 12 October 2021
Project Q3136786 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Study of hippocampus subregions in first episodes of psychosis: Longitudinal analysis at 10 years. |
Project Q3136786 in Spain |
Statements
33,000.0 Euro
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66,000.0 Euro
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50.0 percent
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1 January 2018
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31 March 2021
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CENTRO DE INVESTIGACION BIOMEDICA EN RED (CIBER)
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43°27'43.34"N, 3°48'35.89"W
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39075
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Existe un amplio interés en la caracterización del hipocampo en el campo de la esquizofrenia puesto que es una región que, según varias líneas de evidencia, puede tener un papel principal en anomalías clínicas, funcionales y cognitivas encontradas en esta enfermedad. El objetivo del proyecto presentado es utilizar un método innovador de segmentación de las subregiones del hipocampo para examinar el cambio longitudinal a largo plazo y su asociación con la evolución clínica, cognitiva y funcional a 10 años. Se trata una extensión del estudio longitudinal previo realizado en nuestro centro con la muestra PAFIP (Programa Asistencial Fases Iniciales Psicosis) de Cantabria (PI14/00918 y PI14/00639). Contamos ya con una muestra de 118 pacientes y 116 pacientes con imagen basal y, teniendo en cuenta el seguimiento del estudio previo estimamos que 60-70 pacientes y controles realizarán el seguimiento a 10 años. Es destacable la disponibilidad de la misma RM de 3T y de la misma secuencia inicial que es adecuada para el método de segmentación como hemos podido comprobar en el pilotaje ya desarrollado (ver imagen anexa). Las variables del estudio incluyen 7 subregiones hipocampales, además de variables cognitivas, clínicas, funcionales, genéticas y demográficas de los sujetos. (Spanish)
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There is a broad interest in the characterisation of the hippocampus in the field of schizophrenia since it is a region that, according to several lines of evidence, can play a major role in clinical, functional and cognitive abnormalities found in this disease. The objective of the project presented is to use an innovative method of segmentation of hippocampal subregions to examine long-term longitudinal change and its association with clinical, cognitive and functional 10-year evolution. This is an extension of the previous longitudinal study carried out in our center with the sample PAFIP (Programa Asistencial Fases Initial Psicosis) of Cantabria (PI14/00918 and PI14/00639). We already have a sample of 118 patients and 116 patients with baseline image and, taking into account the follow-up of the previous study, we estimate that 60-70 patients and controls will follow up at 10 years. It is remarkable the availability of the same 3T RM and the same initial sequence that is suitable for the segmentation method as we have been able to check in the piloting already developed (see attached image). The variables of the study include 7 hypocampal subregions, in addition to cognitive, clinical, functional, genetic and demographic variables of the subjects. (English)
12 October 2021
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Santander
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Identifiers
PI17_01056
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