Ratio of pre-adipocyte populations and immunological infiltration of adipose tissue to non-alcoholic fatty liver disease in obese morbids (Q3142214): Difference between revisions
Jump to navigation
Jump to search
(Created claim: summary (P836): Non-alcoholic fatty liver disease (NHSD) is the most prevalent hepatopathy in obese. Its most advanced form, steatohepatitis, is the main cause of cirrhosis and hepatocellular carcinoma in the absence of viral hepatitis and alcoholism. Two of the main pathophysiological mechanisms of obesity have a close relationship with EHGNA: the limit of expansion of fat deposits and chronic inflammation of adipose tissue. Our hypothesis proposes that the...) |
(Changed label, description and/or aliases in en: translated_label) |
||
| label / en | label / en | ||
Ratio of pre-adipocyte populations and immunological infiltration of adipose tissue to non-alcoholic fatty liver disease in obese morbids | |||
Revision as of 13:38, 12 October 2021
Project Q3142214 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Ratio of pre-adipocyte populations and immunological infiltration of adipose tissue to non-alcoholic fatty liver disease in obese morbids |
Project Q3142214 in Spain |
Statements
89,200.0 Euro
0 references
111,500.0 Euro
0 references
80.0 percent
0 references
1 January 2016
0 references
31 January 2020
0 references
FUNDACION PARA LA INVESTIGACION BIOSANITARIA DE ANDALUCIA ORIENTAL - ALEJANDRO OTERO
0 references
37°10'24.60"N, 3°35'58.31"W
0 references
18087
0 references
La enfermedad del hígado graso no-alcohólico (EHGNA) es la hepatopatía más prevalente en obesos. Su forma más avanzada, la esteatohepatitis, es la principal causa de cirrosis y carcinoma hepatocelular en ausencia de hepatitis virales y alcoholismo. Dos de los principales mecanismos fisiopatológicos de la obesidad tienen una estrecha relación con la EHGNA: el límite de expansión de los depósitos de grasa y la inflamación crónica del tejido adiposo. Nuestra hipótesis propone que la intensidad y el tipo de inflamación crónica del tejido adiposo disminuyen la cantidad de preadipocitos y dificultan la respuesta a señales de adipogénesis, limitando la capacidad de expansión del tejido y condicionando la enfermedad hepática por depósito de grasa. Adicionalmente, pensamos que la esteatohepatitis ligada a obesidad puede tener elementos en común con la inflamación de los depósitos de tejido adiposo. Se ha desarrollado una técnica innovadora de citometría de flujo aplicada al tejido que permite cuantificar la cantidad de preadipocitos y la composición de las diferentes poblaciones del infiltrado inmunológico en unidades absolutas (número de células por gramo de tejido). Los objetivos son: 1) Evaluar el papel del tejido adiposo de obesos mórbidos en la EHGNA. 2) Identificar elementos comunes entre la esteatohepatitis ligada a obesidad y la inflamación del tejido adiposo. 3) Analizar en qué medida revierten las alteraciones del tejido adiposo tras una pérdida de peso. Se compararán muestras procedentes de obesos mórbidos sometidos a cirugía bariátrica con muestras de ex-obesos tras una perdida relevante de peso. (Spanish)
0 references
Non-alcoholic fatty liver disease (NHSD) is the most prevalent hepatopathy in obese. Its most advanced form, steatohepatitis, is the main cause of cirrhosis and hepatocellular carcinoma in the absence of viral hepatitis and alcoholism. Two of the main pathophysiological mechanisms of obesity have a close relationship with EHGNA: the limit of expansion of fat deposits and chronic inflammation of adipose tissue. Our hypothesis proposes that the intensity and type of chronic inflammation of the adipose tissue decrease the amount of preadipocytes and hinder the response to signs of adipogenesis, limiting tissue expansion capacity and conditioning liver disease by fat deposits. Additionally, we think that obesity-related steatohepatitis may have elements in common with inflammation of the deposits of adipose tissue. An innovative flow cytometry technique applied to tissue has been developed to quantify the amount of preadipocytes and the composition of the different immune infiltrate populations in absolute units (number of cells per gram of tissue). The objectives are: 1) Evaluate the role of morbid obese tissue adipose tissue in EHGNA. 2) Identify common elements between obesity-related steatohepatitis and inflammation of adipose tissue. 3) Analyse the extent to which adipose tissue alterations are reversed after weight loss. Samples from obese morbids undergoing bariatric surgery shall be compared with ex-obese samples after a relevant weight loss. (English)
12 October 2021
0 references
Granada
0 references
Identifiers
PI15_01361
0 references