“STUDY OF SUBTYPING AND SEARCHING FOR THERAPEUTIC TARGETS THROUGH THE PHENOTYPING OF AGGRESSIVE-IMPULSIVE BEHAVIORS OF PERSONALITY DISORDERS” (Q3136498): Difference between revisions
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(Created claim: summary (P836): Introduction: Aggressive behaviors within impulsive-aggressive personality disorders (TPi-a) pose a serious problem of violence in our society. However, there are still not many studies on endophenotypic patterns that are indicators of therapeutic targets for treatment. Objective: find biochemical endophenotypes underlying impulsive-aggressive personality disorders that guide diagnostic work and the search for therapeutic targets. Metho...) |
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“STUDY OF SUBTYPING AND SEARCHING FOR THERAPEUTIC TARGETS THROUGH THE PHENOTYPING OF AGGRESSIVE-IMPULSIVE BEHAVIORS OF PERSONALITY DISORDERS” | |||
Revision as of 13:28, 12 October 2021
Project Q3136498 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | “STUDY OF SUBTYPING AND SEARCHING FOR THERAPEUTIC TARGETS THROUGH THE PHENOTYPING OF AGGRESSIVE-IMPULSIVE BEHAVIORS OF PERSONALITY DISORDERS” |
Project Q3136498 in Spain |
Statements
45,750.0 Euro
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91,500.0 Euro
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50.0 percent
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1 January 2018
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31 March 2021
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL CLINICO SAN CARLOS
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40°25'0.12"N, 3°42'12.89"W
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28079
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Introducción: Las conductas agresivas dentro de los trastornos de la personalidad impulsivos-agresivos (TPi-a)suponen un grave problema de violencia en nuestra sociedad. A pesar de ello no existen todavía muchos estudios acerca de los patrones endofenotípicos que sean indicadores de dianas terapéuticas para el tratamiento. Objetivo: encontrar endofenotipos bioquímicos subyacentes a los trastornos de la personalidad impulsivo-agresivos que orienten la labor diagnóstica y la búsqueda de dianas terapéuticas. Metodología: se incluirán en el estudio 150 pacientes con TPi-a y 100 controles de 18 a 40 años a los que se les administrará un protocolo sociodemográfico, un protocolo psicopatológico, clínico y psicodiagnóstico, y se les realizará análisis de sangre para obtener muestras de receptores glucocorticoideos, serotonina, oxitocina, factores pro y antiinflamatorios y factores genéticos. (Spanish)
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Introduction: Aggressive behaviors within impulsive-aggressive personality disorders (TPi-a) pose a serious problem of violence in our society. However, there are still not many studies on endophenotypic patterns that are indicators of therapeutic targets for treatment. Objective: find biochemical endophenotypes underlying impulsive-aggressive personality disorders that guide diagnostic work and the search for therapeutic targets. Methodology: the study will include 150 patients with PI-a and 100 controls aged 18 to 40 years who will be given a sociodemographic protocol, a psychopathological, clinical and psychodiagnostic protocol, and blood tests will be performed to obtain samples of glucocorticoid receptors, serotonin, oxytocin, pro and anti-inflammatory factors and genetic factors. (English)
12 October 2021
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Madrid
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Identifiers
PI17_01023
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