Q3141149 (Q3141149): Difference between revisions
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(Created claim: summary (P836): This project includes two related studies whose objectives are: (1) Identify the variables related to clinical management that have an impact on the prognosis of patients with bacteriemia, which serve to establish recommendations and design specific interventional studies (PRO-BAC study), and (2) Identify genetic markers of Escherichia coli and its expression levels in patients with bacteriemia caused by this microorganism that are related to pr...) |
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This project includes two related studies whose objectives are: (1) Identify the variables related to clinical management that have an impact on the prognosis of patients with bacteriemia, which serve to establish recommendations and design specific interventional studies (PRO-BAC study), and (2) Identify genetic markers of Escherichia coli and its expression levels in patients with bacteriemia caused by this microorganism that are related to presentation in the form of severe sepsis and septic shock that serve to design diagnostic or therapeutic techniques (PRO-BAC-Ec study). For the PRO-BAC study, a prospective and multicenter cohort study will be conducted in 28 Spanish hospitals over one year, including patients with clinically significant bacteriemia. The main outcome variable will be raw mortality up to day 30 and the main exposure variables, the specific aspects of clinical management. For the PRO-BAC-Ec study, a study of mated and nested cases and controls in the PRO-BAC cohort will be conducted, with all patients in this cohort with E. coli bacteriemia being eligible; 101 cases (patients with severe sepsis or shock at baseline) and 101 controls (patients without severe sepsis or shock) will be chosen in mating form based on baseline patient characteristics, focus of bacteremia and type of acquisition. A complete sequencing of the genome of the isolates will be performed to identify genes associated with the presentation with severe sepsis or shock, and a transcriptomic analysis of the genes most associated with severe presentation will be performed in selected strains carrying these genes, some causing shock and others not. (English) | |||||||||||||||
| Property / summary: This project includes two related studies whose objectives are: (1) Identify the variables related to clinical management that have an impact on the prognosis of patients with bacteriemia, which serve to establish recommendations and design specific interventional studies (PRO-BAC study), and (2) Identify genetic markers of Escherichia coli and its expression levels in patients with bacteriemia caused by this microorganism that are related to presentation in the form of severe sepsis and septic shock that serve to design diagnostic or therapeutic techniques (PRO-BAC-Ec study). For the PRO-BAC study, a prospective and multicenter cohort study will be conducted in 28 Spanish hospitals over one year, including patients with clinically significant bacteriemia. The main outcome variable will be raw mortality up to day 30 and the main exposure variables, the specific aspects of clinical management. For the PRO-BAC-Ec study, a study of mated and nested cases and controls in the PRO-BAC cohort will be conducted, with all patients in this cohort with E. coli bacteriemia being eligible; 101 cases (patients with severe sepsis or shock at baseline) and 101 controls (patients without severe sepsis or shock) will be chosen in mating form based on baseline patient characteristics, focus of bacteremia and type of acquisition. A complete sequencing of the genome of the isolates will be performed to identify genes associated with the presentation with severe sepsis or shock, and a transcriptomic analysis of the genes most associated with severe presentation will be performed in selected strains carrying these genes, some causing shock and others not. (English) / rank | |||||||||||||||
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| Property / summary: This project includes two related studies whose objectives are: (1) Identify the variables related to clinical management that have an impact on the prognosis of patients with bacteriemia, which serve to establish recommendations and design specific interventional studies (PRO-BAC study), and (2) Identify genetic markers of Escherichia coli and its expression levels in patients with bacteriemia caused by this microorganism that are related to presentation in the form of severe sepsis and septic shock that serve to design diagnostic or therapeutic techniques (PRO-BAC-Ec study). For the PRO-BAC study, a prospective and multicenter cohort study will be conducted in 28 Spanish hospitals over one year, including patients with clinically significant bacteriemia. The main outcome variable will be raw mortality up to day 30 and the main exposure variables, the specific aspects of clinical management. For the PRO-BAC-Ec study, a study of mated and nested cases and controls in the PRO-BAC cohort will be conducted, with all patients in this cohort with E. coli bacteriemia being eligible; 101 cases (patients with severe sepsis or shock at baseline) and 101 controls (patients without severe sepsis or shock) will be chosen in mating form based on baseline patient characteristics, focus of bacteremia and type of acquisition. A complete sequencing of the genome of the isolates will be performed to identify genes associated with the presentation with severe sepsis or shock, and a transcriptomic analysis of the genes most associated with severe presentation will be performed in selected strains carrying these genes, some causing shock and others not. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:27, 12 October 2021
Project Q3141149 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3141149 in Spain |
Statements
102,000.0 Euro
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127,500.0 Euro
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80.0 percent
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1 January 2017
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31 March 2020
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FUNDACION PUBLICA ANDALUZA PARA LA GESTION DE LA INVESTIGACION EN SALUD DE SEVILLA
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37°23'19.07"N, 5°59'43.22"W
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41091
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Este proyecto incluye dos estudios relacionados cuyos objetivos son: (1) Identificar las variables relacionadas con el manejo clínico que tienen impacto en el pronóstico de los pacientes con bacteriemia, que sirvan para establecer recomendaciones y diseñar estudios de intervención específicos (estudio PRO-BAC), y (2) Identificar marcadores genéticos de Escherichia coli y sus niveles de expresión en pacientes con bacteriemia causada por este microorganismo que estén relacionados con la presentación en forma de sepsis grave y shock séptico que sirvan para el diseño de técnicas diagnósticas y/o terapéuticas (estudio PRO-BAC-Ec). Para el estudio PRO-BAC se realizará un estudio de cohortes prospectivo y multicéntrico en 28 hospitales españoles a lo largo de un año, con inclusión de pacientes con bacteriemia clínicamente significativa. La variable resultado principal será la mortalidad cruda hasta el día 30 y las variables de exposición principales, los aspectos específicos del manejo clínico. Para el estudio PRO-BAC-Ec se llevará a cabo un estudio de casos y controles apareados y anidados en la cohorte PRO-BAC, siendo elegibles todos los pacientes de esa cohorte con bacteriemia por E. coli; 101 casos (pacientes con sepsis grave o shock al inicio) y 101 controles (pacientes sin sepsis grave o shock) se elegirán de forma apareada en base a características basales de los pacientes, foco de la bacteriemia y tipo de adquisición. Se realizará una secuenciación completa del genoma de los aislados para identificar genes asociados a la presentación con sepsis grave o shock, y se realizará un análisis trascriptómico de los genes mas asociados a la presentación grave en cepas seleccionadas portadoras estos genes, unas causantes de shock y otras no. (Spanish)
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This project includes two related studies whose objectives are: (1) Identify the variables related to clinical management that have an impact on the prognosis of patients with bacteriemia, which serve to establish recommendations and design specific interventional studies (PRO-BAC study), and (2) Identify genetic markers of Escherichia coli and its expression levels in patients with bacteriemia caused by this microorganism that are related to presentation in the form of severe sepsis and septic shock that serve to design diagnostic or therapeutic techniques (PRO-BAC-Ec study). For the PRO-BAC study, a prospective and multicenter cohort study will be conducted in 28 Spanish hospitals over one year, including patients with clinically significant bacteriemia. The main outcome variable will be raw mortality up to day 30 and the main exposure variables, the specific aspects of clinical management. For the PRO-BAC-Ec study, a study of mated and nested cases and controls in the PRO-BAC cohort will be conducted, with all patients in this cohort with E. coli bacteriemia being eligible; 101 cases (patients with severe sepsis or shock at baseline) and 101 controls (patients without severe sepsis or shock) will be chosen in mating form based on baseline patient characteristics, focus of bacteremia and type of acquisition. A complete sequencing of the genome of the isolates will be performed to identify genes associated with the presentation with severe sepsis or shock, and a transcriptomic analysis of the genes most associated with severe presentation will be performed in selected strains carrying these genes, some causing shock and others not. (English)
12 October 2021
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Sevilla
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Identifiers
PI16_01432
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