Q3141575 (Q3141575): Difference between revisions
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(Created claim: summary (P836): The obestatin system (Ob) and its GPR39 receptor regulate the expression of distinctive proteins of the mesenchymal epithelium transition, angiogenesis, cell morphology, proliferation and invasion of gastric cancer cells. This set of actions leads us to postulate its applicability to antagonise the fundamental mechanisms associated with the development of gastric cancer. Its relationship with pathogenesis or clinical outcome of human gastric ade...) |
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The obestatin system (Ob) and its GPR39 receptor regulate the expression of distinctive proteins of the mesenchymal epithelium transition, angiogenesis, cell morphology, proliferation and invasion of gastric cancer cells. This set of actions leads us to postulate its applicability to antagonise the fundamental mechanisms associated with the development of gastric cancer. Its relationship with pathogenesis or clinical outcome of human gastric adenocarcinomas opens up new avenues for the detection and treatment of gastric cancer. However, the study of its mode of action in the pathogenesis of gastric cancer needs to be deepened, encompassing both cellular and molecular levels as well as physiological mechanisms and associated pathological alterations. The main objective of this proposal is to assess the potential of the Ob/GPR39 system as a therapeutic target in gastric cancer. To this end, an observational study will be conducted of the histological expression of the Ob/GPR39 system, as well as of key proteins in the mechanism of action of this system (GRKs, RTKs, proteases) in human stomachs of patients grouped according to the various stages described for the sequence of progression to gastric cancer. The role of this system throughout these stages will also be studied through ex vivo human stomach systems. The studies are completed with the determination of the bioactive conformation of Ob in the interaction with GPR39 by MRI. (English) | |||||||||||||||
| Property / summary: The obestatin system (Ob) and its GPR39 receptor regulate the expression of distinctive proteins of the mesenchymal epithelium transition, angiogenesis, cell morphology, proliferation and invasion of gastric cancer cells. This set of actions leads us to postulate its applicability to antagonise the fundamental mechanisms associated with the development of gastric cancer. Its relationship with pathogenesis or clinical outcome of human gastric adenocarcinomas opens up new avenues for the detection and treatment of gastric cancer. However, the study of its mode of action in the pathogenesis of gastric cancer needs to be deepened, encompassing both cellular and molecular levels as well as physiological mechanisms and associated pathological alterations. The main objective of this proposal is to assess the potential of the Ob/GPR39 system as a therapeutic target in gastric cancer. To this end, an observational study will be conducted of the histological expression of the Ob/GPR39 system, as well as of key proteins in the mechanism of action of this system (GRKs, RTKs, proteases) in human stomachs of patients grouped according to the various stages described for the sequence of progression to gastric cancer. The role of this system throughout these stages will also be studied through ex vivo human stomach systems. The studies are completed with the determination of the bioactive conformation of Ob in the interaction with GPR39 by MRI. (English) / rank | |||||||||||||||
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| Property / summary: The obestatin system (Ob) and its GPR39 receptor regulate the expression of distinctive proteins of the mesenchymal epithelium transition, angiogenesis, cell morphology, proliferation and invasion of gastric cancer cells. This set of actions leads us to postulate its applicability to antagonise the fundamental mechanisms associated with the development of gastric cancer. Its relationship with pathogenesis or clinical outcome of human gastric adenocarcinomas opens up new avenues for the detection and treatment of gastric cancer. However, the study of its mode of action in the pathogenesis of gastric cancer needs to be deepened, encompassing both cellular and molecular levels as well as physiological mechanisms and associated pathological alterations. The main objective of this proposal is to assess the potential of the Ob/GPR39 system as a therapeutic target in gastric cancer. To this end, an observational study will be conducted of the histological expression of the Ob/GPR39 system, as well as of key proteins in the mechanism of action of this system (GRKs, RTKs, proteases) in human stomachs of patients grouped according to the various stages described for the sequence of progression to gastric cancer. The role of this system throughout these stages will also be studied through ex vivo human stomach systems. The studies are completed with the determination of the bioactive conformation of Ob in the interaction with GPR39 by MRI. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:16, 12 October 2021
Project Q3141575 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3141575 in Spain |
Statements
69,600.0 Euro
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87,000.0 Euro
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80.0 percent
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1 January 2018
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31 March 2021
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FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
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42°52'49.51"N, 8°32'45.10"W
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15078
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El sistema obestatina (Ob) y su receptor GPR39 regulan la expresión de proteínas distintivas de la transición epitelio mesénquima, la angiogénesis, la morfología celular, proliferación e invasión de células cancerígenas gástricas. Este conjunto de acciones nos lleva a postular su aplicabilidad para antagonizar los mecanismos fundamentales asociados al desarrollo del cáncer gástrico. Su relación con la patogénesis y/o resultado clínico de los adenocarcinomas gástricos humanos abre nuevas vías para la detección y tratamiento del cáncer gástrico. Sin embargo, se necesita profundizar en el estudio de su modo de acción en la patogénesis del cáncer gástrico, englobando tanto los niveles celular y molecular como los mecanismos fisiológicos y las alteraciones patológicas asociadas. El objetivo principal de este propuesta es evaluar el potencial del sistema Ob/GPR39 como diana terapéutica en cáncer gástrico. Con este fin, se realizará un estudio observacional de la expresión histológica del sistema Ob/GPR39, así como de proteínas clave en el mecanismo de acción de este sistema (GRKs, RTKs, proteasas) en estómago humano de pacientes agrupados según las diversas etapas descritas para la secuencia de progresión hacia el cáncer gástrico. Asimismo se estudiará la función de este sistema a lo largo de estas etapas mediante sistemas ex vivo de estómago humano. Los estudios se completan con la determinación de la conformación bioactiva de Ob en la interacción con GPR39 mediante RMN. (Spanish)
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The obestatin system (Ob) and its GPR39 receptor regulate the expression of distinctive proteins of the mesenchymal epithelium transition, angiogenesis, cell morphology, proliferation and invasion of gastric cancer cells. This set of actions leads us to postulate its applicability to antagonise the fundamental mechanisms associated with the development of gastric cancer. Its relationship with pathogenesis or clinical outcome of human gastric adenocarcinomas opens up new avenues for the detection and treatment of gastric cancer. However, the study of its mode of action in the pathogenesis of gastric cancer needs to be deepened, encompassing both cellular and molecular levels as well as physiological mechanisms and associated pathological alterations. The main objective of this proposal is to assess the potential of the Ob/GPR39 system as a therapeutic target in gastric cancer. To this end, an observational study will be conducted of the histological expression of the Ob/GPR39 system, as well as of key proteins in the mechanism of action of this system (GRKs, RTKs, proteases) in human stomachs of patients grouped according to the various stages described for the sequence of progression to gastric cancer. The role of this system throughout these stages will also be studied through ex vivo human stomach systems. The studies are completed with the determination of the bioactive conformation of Ob in the interaction with GPR39 by MRI. (English)
12 October 2021
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Santiago de Compostela
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Identifiers
PI17_01707
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