Q3140634 (Q3140634): Difference between revisions
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(Created claim: summary (P836): The normothermal infusion of isolated liver has opened up new possibilities for the recovery of livers from the so-called “Marginal Donors”. This project will seek to assess the possibilities of this technique in three different pig models: 1.- Study the influence of ischemia time on the viability of liver grafts. 2.- Study the possibility of recovery of steatotic livers using normothermal infusion and apheresis techniques. 3.- Study the...) |
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The normothermal infusion of isolated liver has opened up new possibilities for the recovery of livers from the so-called “Marginal Donors”. This project will seek to assess the possibilities of this technique in three different pig models: 1.- Study the influence of ischemia time on the viability of liver grafts. 2.- Study the possibility of recovery of steatotic livers using normothermal infusion and apheresis techniques. 3.- Study the influence of regenerative precondition by normothermal infusion with moderate portal hyperpressure and blood with hepatotrophic factors, on the tolerance of small livers to relative hyperflow that occurs after liver transplantation. (English) | |||||||||||||||
| Property / summary: The normothermal infusion of isolated liver has opened up new possibilities for the recovery of livers from the so-called “Marginal Donors”. This project will seek to assess the possibilities of this technique in three different pig models: 1.- Study the influence of ischemia time on the viability of liver grafts. 2.- Study the possibility of recovery of steatotic livers using normothermal infusion and apheresis techniques. 3.- Study the influence of regenerative precondition by normothermal infusion with moderate portal hyperpressure and blood with hepatotrophic factors, on the tolerance of small livers to relative hyperflow that occurs after liver transplantation. (English) / rank | |||||||||||||||
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| Property / summary: The normothermal infusion of isolated liver has opened up new possibilities for the recovery of livers from the so-called “Marginal Donors”. This project will seek to assess the possibilities of this technique in three different pig models: 1.- Study the influence of ischemia time on the viability of liver grafts. 2.- Study the possibility of recovery of steatotic livers using normothermal infusion and apheresis techniques. 3.- Study the influence of regenerative precondition by normothermal infusion with moderate portal hyperpressure and blood with hepatotrophic factors, on the tolerance of small livers to relative hyperflow that occurs after liver transplantation. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
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Revision as of 13:13, 12 October 2021
Project Q3140634 in Spain
| Language | Label | Description | Also known as |
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| English | No label defined |
Project Q3140634 in Spain |
Statements
40,750.0 Euro
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81,500.0 Euro
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50.0 percent
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1 January 2016
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31 December 2019
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FUNDACION INVESTIGACION BIOMEDICA HOSPITAL GREGORIO MARAÑON
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40°25'0.12"N, 3°42'12.89"W
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28079
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La perfusión normotérmica de hígado aislado ha abierto nuevas posibilidades para la recuperación de hígados provenientes de los llamados “Donantes Marginales”. El presente proyecto tratará de evaluar las posibilidades de ésta técnica en tres modelos porcinos diferentes: 1.- Estudiar la influencia del tiempo de isquemia en la viabilidad de los injertos de hígado. 2.- Estudiar la posibilidad de recuperación de hígados esteatósicos utilizando la perfusión normotérmica y técnicas de aféresis. 3.- Estudiar la influencia del Precondicionemiento regenerativo mediante perfusión normotérmica con hiperpresión portal moderada y sangre con factores hepatotróficos,sobre la tolerencia de los hígados pequeños al hiperaflujo relativo que se produce tras el trasplante hepático. (Spanish)
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The normothermal infusion of isolated liver has opened up new possibilities for the recovery of livers from the so-called “Marginal Donors”. This project will seek to assess the possibilities of this technique in three different pig models: 1.- Study the influence of ischemia time on the viability of liver grafts. 2.- Study the possibility of recovery of steatotic livers using normothermal infusion and apheresis techniques. 3.- Study the influence of regenerative precondition by normothermal infusion with moderate portal hyperpressure and blood with hepatotrophic factors, on the tolerance of small livers to relative hyperflow that occurs after liver transplantation. (English)
12 October 2021
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Madrid
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Identifiers
PI15_01987
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