Mechanisms involved in fetal programming of cardiovascular and kidney disease. Clinical-experimental study (Q3140522): Difference between revisions
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(Created claim: summary (P836): The project sets objectives at the clinical and experimental level. The main objective at the clinical level is to analyse whether the increase in blood pressure (BP) in children aged 6-8 years and adolescents aged 16-17 years with low birth weight is accompanied by an alteration in renal hemodynamics and an increase in the levels of early markers of kidney damage. In addition, it shall be determined whether these changes are associated with var...) |
(Changed label, description and/or aliases in en: translated_label) |
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Mechanisms involved in fetal programming of cardiovascular and kidney disease. Clinical-experimental study | |||
Revision as of 13:12, 12 October 2021
Project Q3140522 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Mechanisms involved in fetal programming of cardiovascular and kidney disease. Clinical-experimental study |
Project Q3140522 in Spain |
Statements
105,200.0 Euro
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131,500.0 Euro
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80.0 percent
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1 January 2017
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31 March 2020
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UNIVERSIDAD DE MURCIA
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37°59'32.57"N, 1°7'49.94"W
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30030
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El proyecto plantea objetivos a nivel clínico y experimental. El objetivo principal a nivel clínico es analizar si el aumento de presión arterial (PA) que tienen los niños de 6-8 años y adolescentes de 16-17 años con bajo peso al nacer, se acompaña de una alteración de la hemodinámica renal y un aumento de los niveles de marcadores precoces de daño renal. Además, se determinará si esos cambios están asociados a variaciones de mediadores y factores de riesgo cardiovascular que modifican la función renal. Finalmente, se estudiará si los cambios mencionados varían en función del peso de los niños y adolescentes, del sexo, y de la causa probable del BPN. Los pacientes serán seleccionados de las bases de datos del Hospital Virgen de la Arrixaca de Murcia. La medida de la PA será realizada por MAPA; el índice de resistencia renal se analizará por ecodoppler, y las medidas de filtración glomerular, de los marcadores precoces de daño renal y de distintos parámetros endocrino-metabolicos se realizarán usando métodos analíticos apropiados. El estudio de los mecanismos responsables de las alteraciones provocadas por la obesidad prolongada en individuos con hipertensión programada durante el desarrollo fetal se realizará con un modelo experimental. Usando técnicas novedosas se analizarán durante 9 meses y en los mismos animales, las variaciones de la PA, hemodinámica renal y de marcadores de inflamación y daño renal. Además, se determinarán las alteraciones de la estructura y función renal a los 9 meses y la implicación de la angiotensina II, analizando si sus efectos están mediados por la activación de procesos inflamatorios y/o un aumento de estrés oxidativo. (Spanish)
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The project sets objectives at the clinical and experimental level. The main objective at the clinical level is to analyse whether the increase in blood pressure (BP) in children aged 6-8 years and adolescents aged 16-17 years with low birth weight is accompanied by an alteration in renal hemodynamics and an increase in the levels of early markers of kidney damage. In addition, it shall be determined whether these changes are associated with variations in mediators and cardiovascular risk factors that modify renal function. Finally, it will be studied whether the above changes vary depending on the weight of children and adolescents, gender, and the probable cause of BPN. Patients will be selected from the databases of the Hospital Virgen de la Arrixaca in Murcia. The AP measure shall be carried out by MAPA; the renal resistance index shall be analysed by ecodoppler, and glomerular filtration measures, early markers of kidney damage and various endocrine-metabolic parameters shall be performed using appropriate analytical methods. The study of the mechanisms responsible for alterations caused by prolonged obesity in individuals with scheduled hypertension during foetal development will be carried out using an experimental model. Using novel techniques, variations in BP, renal hemodynamics and markers of inflammation and kidney damage will be analysed for 9 months and in the same animals. In addition, alterations in renal structure and function at 9 months and involvement of angiotensin II will be determined, analysing whether their effects are mediated by activation of inflammatory processes or increased oxidative stress. (English)
12 October 2021
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Murcia
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Identifiers
PI16_01556
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