Q3138273 (Q3138273): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): Obesity is defined as an excessive or pathological accumulation of fat, but its diagnosis is based on the value of the body mass index (BMI) which does not always take into account the amount of fat mass, its proportion to muscle mass or its anatomical location. Therefore, there is a clinical need to use objective, reliable biochemical markers related to visceral adiposity that are indicative of a danger to the patient. In addition, these biomar...) |
||||||||||||||
| Property / summary | |||||||||||||||
Obesity is defined as an excessive or pathological accumulation of fat, but its diagnosis is based on the value of the body mass index (BMI) which does not always take into account the amount of fat mass, its proportion to muscle mass or its anatomical location. Therefore, there is a clinical need to use objective, reliable biochemical markers related to visceral adiposity that are indicative of a danger to the patient. In addition, these biomarkers should be obtained in a minimally invasive way, with procedures appropriate to clinical practice, reversible and indicative of adiposity after weight loss and at an affordable cost to health systems. With this project we aim to evaluate a liquid biopsy strategy that allows us to develop a profile of epigenomic biomarkers of obesity based on the analysis of gene expression and DNA methylation in circulating leukocytes that represent visceral adiposity and allow us to assess the best strategy for weight loss in a personalised way for each patient as well as the possibility of post-treatment weight gain. To do this, studies will be carried out in subjects with obesity and morbid obesity before and after different hypocaloric diets and different bariatric surgery techniques. (English) | |||||||||||||||
| Property / summary: Obesity is defined as an excessive or pathological accumulation of fat, but its diagnosis is based on the value of the body mass index (BMI) which does not always take into account the amount of fat mass, its proportion to muscle mass or its anatomical location. Therefore, there is a clinical need to use objective, reliable biochemical markers related to visceral adiposity that are indicative of a danger to the patient. In addition, these biomarkers should be obtained in a minimally invasive way, with procedures appropriate to clinical practice, reversible and indicative of adiposity after weight loss and at an affordable cost to health systems. With this project we aim to evaluate a liquid biopsy strategy that allows us to develop a profile of epigenomic biomarkers of obesity based on the analysis of gene expression and DNA methylation in circulating leukocytes that represent visceral adiposity and allow us to assess the best strategy for weight loss in a personalised way for each patient as well as the possibility of post-treatment weight gain. To do this, studies will be carried out in subjects with obesity and morbid obesity before and after different hypocaloric diets and different bariatric surgery techniques. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: Obesity is defined as an excessive or pathological accumulation of fat, but its diagnosis is based on the value of the body mass index (BMI) which does not always take into account the amount of fat mass, its proportion to muscle mass or its anatomical location. Therefore, there is a clinical need to use objective, reliable biochemical markers related to visceral adiposity that are indicative of a danger to the patient. In addition, these biomarkers should be obtained in a minimally invasive way, with procedures appropriate to clinical practice, reversible and indicative of adiposity after weight loss and at an affordable cost to health systems. With this project we aim to evaluate a liquid biopsy strategy that allows us to develop a profile of epigenomic biomarkers of obesity based on the analysis of gene expression and DNA methylation in circulating leukocytes that represent visceral adiposity and allow us to assess the best strategy for weight loss in a personalised way for each patient as well as the possibility of post-treatment weight gain. To do this, studies will be carried out in subjects with obesity and morbid obesity before and after different hypocaloric diets and different bariatric surgery techniques. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 12:33, 12 October 2021
Project Q3138273 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3138273 in Spain |
Statements
81,600.0 Euro
0 references
102,000.0 Euro
0 references
80.0 percent
0 references
1 January 2018
0 references
31 March 2021
0 references
FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA
0 references
42°52'49.51"N, 8°32'45.10"W
0 references
15078
0 references
La obesidad se define como una acumulación excesiva o patológica de grasa, pero su diagnóstico se basa en el valor del índice de masa corporal (IMC) que no siempre tiene en cuenta la cantidad de masa grasa, su proporción con la masa muscular o su localización anatómica. Por tanto, existe la necesidad clínica de utilizar marcadores bioquímicos objetivos, fiables, relacionados con la adiposidad visceral y que sean indicativos de una peligrosidad para el paciente. Además estos biomarcadores deben ser obtenidos de una forma mínimamente invasiva, con procedimientos adecuados a la práctica clínica, reversibles e indicativos de la adiposidad tras una pérdida de peso y con un coste asumible para los sistemas sanitarios. Con este proyecto pretendemos valorar una estrategia de biopsia líquida que nos permita elaborar un perfil de biomarcadores epigenómicos de obesidad a partir del análisis de expresión génica y metilación del ADN en leucocitos circulantes que representen la adiposidad visceral y permitan valorar la mejor estrategia para la pérdida de peso de forma personalizada para cada paciente así como la posibilidad de re-ganancia de peso pos-tratamiento. Para ello se realizarán estudios en sujetos con obesidad y obesidad mórbida antes y después de diferentes dietas hipocalóricas y diferentes técnicas de cirugía bariátrica. (Spanish)
0 references
Obesity is defined as an excessive or pathological accumulation of fat, but its diagnosis is based on the value of the body mass index (BMI) which does not always take into account the amount of fat mass, its proportion to muscle mass or its anatomical location. Therefore, there is a clinical need to use objective, reliable biochemical markers related to visceral adiposity that are indicative of a danger to the patient. In addition, these biomarkers should be obtained in a minimally invasive way, with procedures appropriate to clinical practice, reversible and indicative of adiposity after weight loss and at an affordable cost to health systems. With this project we aim to evaluate a liquid biopsy strategy that allows us to develop a profile of epigenomic biomarkers of obesity based on the analysis of gene expression and DNA methylation in circulating leukocytes that represent visceral adiposity and allow us to assess the best strategy for weight loss in a personalised way for each patient as well as the possibility of post-treatment weight gain. To do this, studies will be carried out in subjects with obesity and morbid obesity before and after different hypocaloric diets and different bariatric surgery techniques. (English)
12 October 2021
0 references
Santiago de Compostela
0 references
Identifiers
PI17_01287
0 references