Q3137983 (Q3137983): Difference between revisions
Jump to navigation
Jump to search
(Changed an Item: Edited by the materialized bot - inferring region from the coordinates) |
(Created claim: summary (P836): SUMMARY: Background: DM1 is a multisystem disease that includes CNS involvement but whose evolutionary deterioration pattern is little known, with little longitudinal data of structural neuroimage and none of functional (fMRI). Objectives: 1) Describe the characteristics of cognitive impairment, its evolutionary profile and its possible relationship with the structural pattern and brain connectivity in fMRI and 2) analyse the correlation betwe...) |
||||||||||||||
| Property / summary | |||||||||||||||
SUMMARY: Background: DM1 is a multisystem disease that includes CNS involvement but whose evolutionary deterioration pattern is little known, with little longitudinal data of structural neuroimage and none of functional (fMRI). Objectives: 1) Describe the characteristics of cognitive impairment, its evolutionary profile and its possible relationship with the structural pattern and brain connectivity in fMRI and 2) analyse the correlation between these changes and the biological age of the patient. Participants: 121 patients with molecularly confirmed DM1 from a cohort previously evaluated. Neuroimaging and biological age estimation studies will have a control sample composed of healthy participants matched by gender, age and educational level. Intervention: Two follow-up neuropsychological evaluations will be performed in patients with DM1 studied for the first time 10 years ago. The neuroimage will include voxel-based Morphometry, Diffusion Tenser, and Resting State. Biological blood samples stored, as well as those obtained during the project, will be analysed simultaneously for genetic characterisation (CTG expansion size) and biological age determination. (English) | |||||||||||||||
| Property / summary: SUMMARY: Background: DM1 is a multisystem disease that includes CNS involvement but whose evolutionary deterioration pattern is little known, with little longitudinal data of structural neuroimage and none of functional (fMRI). Objectives: 1) Describe the characteristics of cognitive impairment, its evolutionary profile and its possible relationship with the structural pattern and brain connectivity in fMRI and 2) analyse the correlation between these changes and the biological age of the patient. Participants: 121 patients with molecularly confirmed DM1 from a cohort previously evaluated. Neuroimaging and biological age estimation studies will have a control sample composed of healthy participants matched by gender, age and educational level. Intervention: Two follow-up neuropsychological evaluations will be performed in patients with DM1 studied for the first time 10 years ago. The neuroimage will include voxel-based Morphometry, Diffusion Tenser, and Resting State. Biological blood samples stored, as well as those obtained during the project, will be analysed simultaneously for genetic characterisation (CTG expansion size) and biological age determination. (English) / rank | |||||||||||||||
Normal rank | |||||||||||||||
| Property / summary: SUMMARY: Background: DM1 is a multisystem disease that includes CNS involvement but whose evolutionary deterioration pattern is little known, with little longitudinal data of structural neuroimage and none of functional (fMRI). Objectives: 1) Describe the characteristics of cognitive impairment, its evolutionary profile and its possible relationship with the structural pattern and brain connectivity in fMRI and 2) analyse the correlation between these changes and the biological age of the patient. Participants: 121 patients with molecularly confirmed DM1 from a cohort previously evaluated. Neuroimaging and biological age estimation studies will have a control sample composed of healthy participants matched by gender, age and educational level. Intervention: Two follow-up neuropsychological evaluations will be performed in patients with DM1 studied for the first time 10 years ago. The neuroimage will include voxel-based Morphometry, Diffusion Tenser, and Resting State. Biological blood samples stored, as well as those obtained during the project, will be analysed simultaneously for genetic characterisation (CTG expansion size) and biological age determination. (English) / qualifier | |||||||||||||||
point in time: 12 October 2021
| |||||||||||||||
Revision as of 12:32, 12 October 2021
Project Q3137983 in Spain
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
Project Q3137983 in Spain |
Statements
43,500.0 Euro
0 references
87,000.0 Euro
0 references
50.0 percent
0 references
1 January 2018
0 references
31 March 2021
0 references
ASOCIACION INSTITUTO BIODONOSTIA
0 references
43°19'20.71"N, 1°59'2.00"W
0 references
20069
0 references
RESUMEN: Antecedentes: La DM1es una enfermedad multisistémica que incluye afectación del SNC pero cuyo patrón de deterioro evolutivo es poco conocido, con escasos datos longitudinales de neuroimagen estructural y ninguna de funcional (fMRI). Objetivos: 1) Describir las características del deterioro cognitivo, su perfil evolutivo y su posible relación con el patrón estructural y de conectividad cerebral en fMRI y 2) analizar la correlación entre estos cambios y la edad biológica del paciente. Participantes: 121 pacientes con DM1 confirmada molecularmente procedentes de una cohorte evaluada previamente. Los estudios de neuroimagen y de estimación de la edad biológica contarán con una muestra control compuesta por participantes sanos pareados por género, edad y nivel educativo. Intervención: Se realizarán dos evaluaciones neuropsicológicas de seguimiento a los pacientes con DM1 estudiados por primera vez 10 años atrás. La neuroimagen incluirá Morfometría basada en voxels, Tensor de Difusión y Resting state. Las muestras biológicas de sangre almacenadas, así como las obtenidas durante el proyecto se analizarán simultáneamente para la caracterización genética (tamaño de la expansión CTG) y la determinación de la edad biológica. (Spanish)
0 references
SUMMARY: Background: DM1 is a multisystem disease that includes CNS involvement but whose evolutionary deterioration pattern is little known, with little longitudinal data of structural neuroimage and none of functional (fMRI). Objectives: 1) Describe the characteristics of cognitive impairment, its evolutionary profile and its possible relationship with the structural pattern and brain connectivity in fMRI and 2) analyse the correlation between these changes and the biological age of the patient. Participants: 121 patients with molecularly confirmed DM1 from a cohort previously evaluated. Neuroimaging and biological age estimation studies will have a control sample composed of healthy participants matched by gender, age and educational level. Intervention: Two follow-up neuropsychological evaluations will be performed in patients with DM1 studied for the first time 10 years ago. The neuroimage will include voxel-based Morphometry, Diffusion Tenser, and Resting State. Biological blood samples stored, as well as those obtained during the project, will be analysed simultaneously for genetic characterisation (CTG expansion size) and biological age determination. (English)
12 October 2021
0 references
Donostia/San Sebastián
0 references
Identifiers
PI17_01231
0 references