Revision history of "Preclinical study with messenger RNA for etiological treatment of intermittent acute porphyria. Efficacy and safety in non-human primates and in a new model of liver porphyria in rabbit." (Q3167120)

8 October 2024

• curprev 10:5210:52, 8 October 2024‎ DG Regio talk contribs‎ 86,217 bytes +4‎ ‎Changed label, description and/or aliases in pt
• curprev 10:5210:52, 8 October 2024‎ DG Regio talk contribs‎ 86,213 bytes −14‎ ‎Set a claim value: summary (P836): A porfiria aguda intermitente (IAPA), a haploinsuficiência de porfobilinogénio desaminase hepática (PBGD), caracteriza-se por crises abdominó-psíquicas-neurológicas intermitentes associadas à acumulação sérica de precursores hepáticos do hemo. Ensaios em ratinhos PAI e num novo modelo de coelho propõem a administração sistémica de ARN mensageiro em nanopartículas lipídicas como um tratamento etiológico promissor para MYP. Esta terapia funciona dentr...

20 March 2024

• curprev 14:0814:08, 20 March 2024‎ DG Regio talk contribs‎ 86,227 bytes +288‎ ‎Added qualifier: readability score (P590521): 0.1910559901301747

20 December 2023

• curprev 17:0417:04, 20 December 2023‎ DG Regio talk contribs‎ 85,939 bytes +7‎ ‎Changed an Item

12 June 2023

• curprev 14:0814:08, 12 June 2023‎ DG Regio talk contribs‎ 85,932 bytes +540‎ ‎Changed an Item

10 June 2023

• curprev 06:5606:56, 10 June 2023‎ Admin talk contribs‎ 85,392 bytes +437‎ BatchIngestion

18 August 2022

• curprev 02:0802:08, 18 August 2022‎ DG Regio talk contribs‎ 84,955 bytes +58,828‎ ‎Changed label, description and/or aliases in el, da, fi, mt, lv, sk, ga, cs, pt, et, hu, bg, lt, hr, sv, ro, sl, pl, nl, fr, de, it, es, and other parts: Adding translations: el, da, fi, mt, lv, sk, ga, cs, pt, et, hu, bg, lt, hr, sv, ro, sl, pl,

16 January 2022

• curprev 13:4013:40, 16 January 2022‎ DG Regio talk contribs‎ 26,127 bytes +3,077‎ ‎Changed label, description and/or aliases in it, and other parts: Adding Italian translations

17 December 2021

• curprev 13:2813:28, 17 December 2021‎ DG Regio talk contribs‎ 23,050 bytes +3,080‎ ‎Changed label, description and/or aliases in nl, and other parts: Adding Dutch translations

9 December 2021

• curprev 13:3013:30, 9 December 2021‎ DG Regio talk contribs‎ 19,970 bytes +3,183‎ ‎Changed label, description and/or aliases in de, and other parts: Adding German translations

4 December 2021

• curprev 12:3512:35, 4 December 2021‎ DG Regio talk contribs‎ 16,787 bytes +3,342‎ ‎Changed label, description and/or aliases in fr, and other parts: Adding French translations

12 October 2021

• curprev 16:5416:54, 12 October 2021‎ DG Regio talk contribs‎ 13,445 bytes +246‎ ‎Changed label, description and/or aliases in en: translated_label
• curprev 16:5416:54, 12 October 2021‎ DG Regio talk contribs‎ 13,199 bytes +2,647‎ ‎Created claim: summary (P836): Intermittent acute porphyria (IAPA), haploinsufficiency of liver porfobilinogen desaminase (PBGD), is characterised by intermittent abdomino-psychic-neurological crises associated with serum accumulation of hepatic haemo precursors. Trials in PAI mice and in a new rabbit model propose systemic administration of messenger RNA in lipid nanoparticles as a promising etiological treatment for MYP. This therapy works within a few hours and maintains e...

10 October 2021

• curprev 18:2718:27, 10 October 2021‎ DG Regio talk contribs‎ 10,552 bytes +427‎ ‎Changed an Item: Edited by the materialized bot - inferring region from the coordinates

9 October 2021

• curprev 13:4113:41, 9 October 2021‎ DG Regio talk contribs‎ 10,125 bytes +499‎ ‎Changed an Item: Edited by the infer coords bot - inferring coordinates from location

8 October 2021

• curprev 08:2208:22, 8 October 2021‎ DG Regio talk contribs‎ 9,626 bytes −11‎ ‎Changed label, description and/or aliases in en
• curprev 08:2208:22, 8 October 2021‎ DG Regio talk contribs‎ 9,637 bytes +9,637‎ ‎Created a new Item