Revision history of "MOLECULAR AND GENE THERAPY STUDY FOR TYPE VII MUCOPOLYSACCHARIDOSIS." (Q3144292)

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10 October 2024

  • curprev 09:3809:38, 10 October 2024DG Regio talk contribs 69,465 bytes 0 Changed label, description and/or aliases in pt
  • curprev 09:3809:38, 10 October 2024DG Regio talk contribs 69,465 bytes +24 Set a claim value: summary (P836): Pouco se sabe sobre os mecanismos moleculares envolvidos na neurodegeneração precoce na mucopolissacaridose (MPS). Por outro lado, estudos de longo prazo em modelos MPS VII sugerem que a patologia óssea na coluna vertebral pode ser difícil de corrigir, mesmo com níveis elevados de enzimas séricas. O principal objetivo deste projeto é, por um lado, compreender como o acúmulo de glicosaminoglicanos nos lisossomos leva à neurodegeneração e, por outro,...

7 March 2024

20 December 2023

12 June 2023

10 June 2023

17 August 2022

  • curprev 20:5620:56, 17 August 2022DG Regio talk contribs 68,168 bytes +46,365 Changed label, description and/or aliases in el, da, fi, mt, lv, sk, ga, cs, pt, et, hu, bg, lt, hr, sv, ro, sl, pl, nl, fr, de, it, es, and other parts: Adding translations: el, da, fi, mt, lv, sk, ga, cs, pt, et, hu, bg, lt, hr, sv, ro, sl, pl,

16 January 2022

17 December 2021

9 December 2021

2 December 2021

  • curprev 15:3015:30, 2 December 2021DG Regio talk contribs 14,649 bytes +2,424 Created claim: summary (P836): On sait peu de choses sur les mécanismes moléculaires impliqués dans la neurodégénérescence précoce dans la mucopolysaccharidose (SMP). D’autre part, des études à long terme sur des modèles MPS VII suggèrent que la pathologie osseuse dans la colonne vertébrale peut être difficile à corriger, même avec des niveaux élevés d’enzymes sériques. L’objectif principal de ce projet est, d’une part, de comprendre comment l’accumulation de glycosaminoglyca...
  • curprev 15:3015:30, 2 December 2021DG Regio talk contribs 12,225 bytes +145 Changed label, description and/or aliases in fr: translated_label

12 October 2021

  • curprev 14:0114:01, 12 October 2021DG Regio talk contribs 12,080 bytes +127 Changed label, description and/or aliases in en: translated_label
  • curprev 14:0114:01, 12 October 2021DG Regio talk contribs 11,953 bytes +2,103 Created claim: summary (P836): Little is known about the molecular mechanisms involved in early neurodegeneration in the Mucopolysaccharidosis (MPS). On the other hand, long-term studies in MPS VII models suggest that bone pathology in the spine may be difficult to correct, even with elevated serum enzyme levels. The main objective of this project is on the one hand to understand how the accumulation of glycosaminoglycans in lysosomes leads to neurodegeneration and on the oth...

10 October 2021

9 October 2021

8 October 2021